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Molecular Biology of Parasitic Protozoa

Protozoans are interesting creatures for several reasons, not least of which is their ability to live inside or among the cells of their host while resisting the host's cellular defences. The rigours of their lifestyle have resulted in the evolution of some remarkable adaptation at the biochemical level; many parasites have dispensed with entire metabolic pathways, and have evolved complex mechanisms for transmission to new hosts. Parasitic protozoa cause some of the major infectious diseases of humans and domestic animals. In recent years, new molecular biological techniques have opened up the study of the biology of these parasites, and tremendous advances have been made. This book covers this interesting and fast-moving field at an advanced level for which there is no other up-to-date book.
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Table of Contents

1. Trypanosomatid genetics ; 2. The three genomes of Plasmodium ; 3. Toxoplasma as a model genetic system ; 4. Kinetoplast DNA: structure and replication ; 5. Developmental regulation of gene expression in African trypanosomes ; 6. Trans-splicing in trypanosomatid protozoa ; 7. RNA editing. Post-transcriptional restructuring of genetic information ; 8. Biogenesis of specialized organelles: glycosomes and hydrogenosomes ; 9. Mechanism of drug resistance in protozoan parasites ; 10. Glycosyl-phosphatidylinositols and the surface architecture of parasitic protozoa


It is ... timely that a new book on the subject should be published in a series designed to report on front-line molecular biological research ... this is a good book. * Brian J. Kilbey, University of Edinburgh, Genetical Research, Vol. 69 - 1997 *

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