Table of Contents
Table of Contents Section 1 General Strategies for Molecular
Targeting in Oncology Chapter 1 The Cell Cycle: Therapeutic
Targeting of Cell Cycle Regulatory Components and Effector Pathways
in Cancer Chad D. Knights and Richard G. Pestell Chapter 2 mTOR:
Properties and Therapeutics John B. Easton and Peter J. Houghton
Chapter 3 Ras/Raf/MEK Inhibitors Joseph A. Sparano Chapter 4 17AAG:
Targeting the Molecular Chaperone Heat Shock Protein 90 Len Neckers
and Percy Ivy Chapter 5 The Cancer Epigenome: Can it be targeted
for therapy? Sam Thiagalingam and Douglas V. Faller Section 2
Molecular Targeting for Specific Disease Sites Chapter 6 Molecular
targeting in upper gastrointestinal malignancies Scott Wadler
Chapter 7 Molecular Targeting of Colorectal Cancer: An Idea Whose
Time Has Come Mark L. Sundermeyer, Alfonso Bellacosa, and Neal J.
Meropol Chapter 8 Molecular Targeting in Hepatocellular Carcinoma
Jonathan D. Schwartz. and Josep M. Llovet Chapter 9 Molecularly
Targeted Therapy in Pancreatic Cancer Anupama Goel and Peter Kozuch
Chapter 10 Untargeted Use of Targeted Therapy: A Dilemma in
Non-Small Cell Lung Cancer Cheryl Ho, Angela M. Davies, Primo N.
Lara, O. Gautschi, P.C. Mack, Paul H. Gumerlock and David R.
Gandara Chapter 11 Molecular Targeting in Oncology: Renal Cell
Cancer Olwen Hahn and Walter Stadler Chapter 12 Targeted Therapies
for Prostate Cancer Elisabeth I. Heath and Michael A. Carducci
Chapter 13 Molecular Targets in Ovarian Cancer and Endometrial
Cancer Nilofer S. Azad, Gisele Sarosy, and Elise C. Kohn Chapter 14
Targeted Therapy for Breast Cancer Deena M. Atieh and Linda T.
Vahdat Chapter 15 Melanoma Akshay Gupta and John M. Kirkwood
Section 3 Classes of Drugs for Molecular Targeting in Oncology
Chapter 16 Antibody Therapy of Cancer Hossein Borghaei, Liat
Binyamin, Igor Astsaturov, and Louis M. Weiner Chapter 17 Nucleic
Acid Therapies for Cancer Treatment Dan T. Vogl and Alan M. Gewirtz
Chapter 18 Engineering Oncolytic Measles Viruses for Targeted
Cancer Therapy Takafumi Nakamura and Stephen J. Russell Chapter 19
Vaccines as Targeted Cancer Therapy Miguel-Angel Perales, Jedd D.
Wolchok and Howard L. Kaufman Chapter 20 Cytokine based therapy for
cancer Henry B. Koon and Michael B. Atkins Chapter 21
Cyclooxygenase-2 (Cox-2) as a Target for Cancer Prevention and
Treatment Monica Bertagnolli, Jaye L. Viner, and Ernest T. Hawk
Section 4 Specific Drugs for Molecular Targeting in Oncology
Chapter 22 Imatinib Mesylate (Gleevec) and the emergence of
chemotherapeutic drug-resistant mutation Gerald V. Denis Chapter 23
Development of a Targeted Treatment for Cancer: The Example of C225
(Cetuximab) John Mendelsohn Chapter 24 VEGF Inhibition for Cancer
Therapy Shermini Saini and Herbert Hurwitz Chapter 25 Somatostatin
analogue therapy Manish C. Champaneria, M.D., Irvin M. Modlin,
M.D., Ph.D., D.Sc., Igor Latich, M.D., Jan Bornschein, Ignat
Drozdov, Mark Kidd, Ph.D. Section 5 Challenges in Molecular
Targeting in Oncology Chapter 26 Patient Selection for Rational
Development of Novel Anticancer Agents Grace K. Dy and Alex A.
Adjei Chapter 27 Clinical Trial Design with Targeted Agents Sarita
Dubey and Joan H. Schiller Chapter 28 How to define treatment
success or failure if tumors don't shrink: Consequences for trial
design. JJEM Kitzen, MJA de Jonge, and J Verweij Chapter 29
Molecular Imaging in Oncology Lalitha Shankar, Anne Menkens, and
Daniel C. Sullivan Chapter 30 Combinations of Molecular Targeted
Therapies - Opportunities and Challenges Helen X. Chen and Janet E.
Dancey Chapter 31 Preclinical Development of Molecularly Targeted