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Mood and Anxiety Related Phenotypes in Mice

Affecting approximately twenty percent of the world population, mood and anxiety disorders have been the subject of ever-increasing research. This increased research parallels a remarkable growth in the use of the laboratory mouse as a tool to understand the biological and genetic basis of mood and anxiety disorders as well as to develop improved treatments. In Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, world-renowned researchers provide an overview of behavioral approaches utilized in the characterization of mood and anxiety related behaviors in mice as well as commonly used behavioral assays to assess the potential antidepressant and anxiolytic efficacy of novel compounds. As a volume in the successful Neuromethods (TM) series, the chapters provide authoritative reviews including up-to-date detailed protocols of the most commonly used approaches in the field. Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests is an ideal resource for scientists actively pursuing or interested in establishing behavioral protocols in their laboratories, while also serving as a reference for those students, scientists, and practitioners who have an interest in better understanding the preclinical behavioral methods used in mood and anxiety research.
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Table of Contents

1. The Open Field Test Todd D. Gould, David T. Dao, and Colleen E. Kovacsics 2. Analysis of Grooming Behavior and its Utility in Studying Animal Stress, Anxiety, and Depression Amanda N. Smolinsky, Carisa L. Bergner, Justin L. LaPorte, and Allan V. Kalueff 3. Digging in Mice: Marble Burying, Burrowing, and Direct Observation Reveal Changes in Mouse Behavior Robert M.J. Deacon 4. Circadian and Light Modulation of Behavior Cara M. Altimus, Tara A. LeGates, and Samer Hattar 5. Ultrasonic Vocalizations by Infant Mice: An Ethological Expression of Separation Anxiety James T. Winslow 6. The Forced Swimming Test in Mice: A Suitable Model to Study Antidepressants Martine Hascoet and Michel Bourin 7. The Tail Suspension Test: A Model for Characterizing Antidepressant Activity in Mice Olivia F. O'Leary and John F. Cryan 8. Stress-Induced Hyperthermia in the Mouse Christiaan Vinkers, Ruud van Oorschot, Berend Olivier, and Lucianne Groenink 9. Factors of Reproducibility of Anhedonia Induction in a Chronic Stress Depression Model in Mice Tatyana Strekalova and Harry Steinbusch 10. Learned Helplessness in Mice Hymie Anisman and Zul Merali 11. The Mouse Light-Dark Box Test Martine Hascoet and Michel Bourin 12. Using the Elevated Plus Maze as a Bioassay to Assess the Effects of Naturally-Occurring, and Exogenously-Administered Compounds, to Influence Anxiety-Related Behaviors of Mice Alicia A. Walf and Cheryl A. Frye 13. Novelty-Induced Hypophagia Stephanie C. Dulawa 14. Acute and Chronic Social Defeat: Stress Protocols and Behavioral Testing Alessandro Bartolumucci, Eberhard Fuchs, Jaap M. Koolhaas, and Frauke Ohl 15. Reduction of SubmissiveBehavior Model for Antidepressant Drug Testing in Mice Ewa Malatynska, Albert Pinhasov, and Richard J. Knapp 16. Mice Models for the Manic Pole of Bipolar Disorder Shlomit Flaisher-Grinberg and Haim Einat


From the reviews: "Part of the Neuromethods Series, this book describes behavioral protocols that are used in laboratory experiments with mice in order to understand mood and anxiety related phenotypes. ... This excellent book describes specific behavioral tests in great detail. Readers who have a strong foundation in research will be very pleased because they can replicate the tests with the information here and the protocols are analyzed in terms of their usefulness." (Gary B. Kaniuk, Doody's Review Service, June, 2010)

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