PHYSICAL PRINCIPLES. Classical Magnitudes and Scaling Laws. Potential Energy Surfaces. Molecular Dynamics. Positional Uncertainty. Transitions, Errors, and Damage. Energy Dissipation. Mechanosynthesis. COMPONENTS AND SYSTEMS. Nanoscale Structural Components. Mobile Interfaces and Moving Parts. Intermediate Subsystems. Nanomechanical Computational Systems. Molecular Sorting, Processing, and Assembly. Molecular Manufacturing Systems. IMPLEMENTATION STRATEGIES. Macromolecular Engineering. Paths to Molecular Manufacturing. Appendices. Afterword. Symbols, Units, and Constants. Glossary. References. Index.