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Neuroimaging in Dementia


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Clinical background: Definition of dementia. Prevalence and incidence. Nosological approach. Differential diagnosis. Multi-disciplinary integration.- The toolbox: Structural imaging. Feature extraction. Advanced MR techniques. SPECT and PET.- Normal Ageing: Brain volume loss. Enlarged perivascular (Virchow-Robin) spaces and lacunes. Age-related white matter changes. Iron accumulation. Hidden age-related changes in brain tissue.- Primary gray matter loss: Alzheimer's disease. Frontotemporal lobar degeneration. Dementia with Parkinsonism. Dementia in other movement disorders. Prion-linked dementias. Recreational drugs and alcohol.- Vascular Disease: history and nosology. Large vessel vascular dementia. Small vessel vascular dementia. Vasculitis. Systemic hypoxia. Mixed dementia and interrelationship VaD/AD.- Disorders mainly affecting white matter: Infections. Inflammatory disorders. Inborn errors of metabolism. Toxic leukencephalopathy and dementia. Post-therapy effect. Trauma.- Dementias with associated brain swelling. Giant VRS. Infections. Neoplastic disease and radiation necrosis. Auto-immune limbic encephalitis. Normal pressure hydrocephalus (NPH). Arteriovenous malformation (AVM) and fistula (AVF). Reversible posterior leukencephalopathy (RPLS). Anti-amyloid therapy.


From the reviews: "Neuroimaging in Dementia is an excellent textbook on the clinical applications of neuroimaging in a variety of dementia disorders. ... it is a clinical guide. ... Overall, this is an outstanding textbook, providing many examples of the uses of neuroimaging techniques in the clinical assessment of dementia. The clinical approach and algorithms make this a unique book for radiologists, geriatricians, neurologists, and psychiatrists, who will continue to rely heavily on these neuroimaging techniques in the assessment and management of their patients." (Andrew Newberg, The Lancet Neurology, Vol. 10, June, 2011) "The book categorizes diseases into four main groups by dominant imaging patterns visible by magnetic resonance imaging (MRI): grey matter loss, vascular dementia, white matter disorder, and brain swelling. ... Then it shows full-color examples ... of the scans that typify progression of the disease: MRI, single photon emission computed tomography (SPECT), and positron emission tomography (PET), among them. ... 'Beautifully illustrated and well-balanced, its intelligent design contains the collective wisdom of a team of internationally acclaimed cognitive and neurologists and neuroradiologists.'" (Gwyneth Dickey Zakaib, Alzheimer Research Forum, July, 2011) "This is an excellent, comprehensive first edition book on practical use of neuroimaging in dementia. ... Everyday language with use of diagrams, flow charts and coloured text boxes highlighting 'take home' information gives the feeling of listening to a good lecture ... . I thoroughly recommend this book to all radiologists, senior radiology trainees and clinicians with an interest in dementia. With the current interest in dementia and the increasing use of imaging, this would be essential reading to all radiologists." (Ravi V. Jampana, Neuroradiology, Vol. 54 (4), April, 2012)

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