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Next Generation Sequencing Technologies in Medical Genetics

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Sanger sequencing principles, history and landmarks.- A survey of next-generation sequencing technologies.- A review of DNA enrichment technologies.- Application of next-generation sequencing to the diagnosis of genetic disorders a brief overview.- Next-generation sequencing-based noninvasive prenatal diagnosis.- Diagnosis of inherited neuromuscular disorders by next-generation sequencing.- Application of next-generation sequencing in hearing loss diagnosis.- Exome sequencing as a discovery and a diagnostic tool.- Challenges of next-generation sequencing-based molecular diagnostics.

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