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Nitric Oxide in Transplant Rejection and Anti-Tumor Defense represents a unique combination of three interrelated topics that is unavailable in any other single work: * The detection and visualization of nitric oxide in biological materials using EPR spectroscopy and EPR imaging; * Nitric oxide in immune mechanisms of allograft rejection; and * The involvement of nitric oxide in anti-tumor defense. By bringing together specialists from these three disciplines, the book investigates the common molecular and cellular mechanisms underlying phenomena in transplants and oncology. In addition, the book provides an introduction to biological applications of EPR spectroscopy and imaging. Nitric Oxide in Transplant Rejection and Anti-Tumor Defense will appeal to researchers and graduate-level students investigating transplant rejections and their immune mechanisms, anti-tumor immune defenses, novel types of contrast agents for EPR imaging, and biological applications of EPR spectroscopy and EPR imaging.
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Table of Contents

Part I: Electron Paramagnetic Resonance Spectroscopy and Imaging as Research Tools. 1. EPR Detection of Nitrosylated Compounds: Introduction with Some Historical Background; Y. Henry, A. Guissani. 2. Principles of EPR Spectroscopy for Measurement of Free Radicals in Biological Tissues; J.L. Zweier, P. Kuppusamy. 3. EPR Studies and Biological Implications of Nitrosyl Nonheme Iron Complexes; A.N. Vanin, A.L. Kleschyov. 4. Enzyme Independent Formation of Nitric Oxide in Tissues; J.L. Zweier, et al. 5. Spin-Label No-Metry in Lipid Bilayer Membranes; W.K. Subczynski, J.S. Hyde. 6. EPR Imaging of Free Radicals in Biological Systems; P. Kuppusamy, J.L. Zweier. 7. Electron Paramagnetic Resonance Imaging of Nitric Oxide in Tissues; P. Kuppusamy, et al. Part II: Allo- and Xenograft Rejection. 8. Allograft Rejection: Fact and Fancy; J.W. Kupiec-Weglinski. 9. Immunobiology of Transplants: Specific and Nonspecific Mechanisms Involved in Allograft Rejection; S.M. Stepkowski. 10. Animal EPR Studies on Allo- and Xenograft Rejection; S. Lukiewicz, et al. 11. Nitric Oxide Effects on Murine Cardiac Allografts; N.R. Bastian, et al. 12. Accelerated Rejection of Cardiac Allo- and Xenografts in Pre-Sensitized Rats and Gerbils; P. Plonka, et al. 13. Involvement of Nitric Oxide in Amphibian Transplantation Immunity; A. Jozkowicz, B. Plytycz. Part III: Antitumor Immune Responses. 14. Interactions Between Cytokine Induced Nitric Oxide and Intracellular Iron; J.B. Hibbs, Jr., N.R. Bastian. 15. Molecules Involved in the Recruitment and Regulation of Tumor-Associated Macrophages; S. Sozzani, et al. 16. The Role of Macrophage-Derived Nitric Oxide in Tumor Cell Death; J.S. Reichner, J.E. Albina. 17. Transcriptional Regulation of the Macrophage NOS2 Gene; Ch. Goldring, et al. 18. Infection, Inflammation and Cancer Mediated by Oxygen Radicals and Nitric Oxide; H. Maeda, T. Akaike. 19. Induction of Iron-Nitric Oxide EPR Signals in Murine Cancers: Effects of Thiols and Cytokine-Induced Oxidant Stress; N.R. Bastian, et al. 20. EPR Analysis of Tumor-Host Interactions; P. Plonka, et al. 21. Ambivalent Role for NO in the Antitumor Immune Response; P. Lagadec, et al. 22. Identification of Nitric Oxide-Derived EPR Signals in Human Cancers; W.E. Samlowski, et al. 23. EPR Signals Detectable in Human Tumors; S. Lukiewicz, et al. Subject Index.

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