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Nitric Oxide and Cancer

Advances in Nitric Oxide and Cancer is a volume that serves to give the latest research on nitric oxide (NO) and cancer. More specifically, the volume reviews significant advances in the application of NO-mediated drugs. The volume explores nitric oxide and its relationship to cancer spanning from its roles in the pathogenesis, prognosis, gene and protein modifications, regulation of resistance to cytotoxics, and therapeutic applications. With chapters written by leading experts, the volume addresses the burgeoning interest in a rapidly advancing field and provides a valuable resource to scientists who have initiated research as well as clinical investigations in their laboratories on the various roles of NO and cancer.
Product Details

Table of Contents

Part I: Molecular Cell Signaling by NO in cancer1. Inflammation-associated Carcinogenesis Involved Interaction Between with iNOS/NO and WNT/beta-cateninQiang Du and David A. Geller 2. NO and Genomic StabilityVasily A. Yakovlev3. Targeting Hyponitroxia in Cancer TherapyBryan Oronsky, Neil Oronsky, Michelle Lybeck, Gary Fanger, Jan Scicinski4. Mechanism of NO-dependent Regulation of Invasion and MetastasisAideen E Ryan, Amy J Burke, Francis J Giles, Francis J Sullivan, Sharon A Glynn5. NO Role in Protumorigenesis and HypoxiaLynne-Marie PostovitPart II: S-nitrosylation and cancer6. Impacts of S-nitrosylation in CancerTysha N. Medeiros, Dana M. Jarigese, Melissa A. Edwards and Mark A. Brown7. S-nitrosylation of Cancer CellsAli Bettaieb, Stephanie Plenchette, Catherine Paul, Veronique Laurens, Sabrina Romagny, Jean-Francois Jeannin8. Role of S-nitrosylation in Cancer MetastasisSudjit Luanpitpong and Yon RojanasakulPart III: Modulation of anti-tumor immune responses by NO9. NO Immunity and CancerHermes J. Garban10. Regulation of Anti-tumor Responses by NOPeter Siesjoe11. NO Immune Modulation and Tumor GrowthNaveena B. Janakiram and Chinthalapally V. RaoPart IV: Therapeutics and overcoming resistance 12. Role of NO in Chemo-immune ResistanceBenjamin Bonavida 13. Emerging Role of NO-mediated TherapeuticsCian M. McCrudden and Helen O. McCarthy14. PDT and NOEmilia Della Pietra and Valentina Rapozzi15. Regulation of Cell Death by NOJordi Muntane, Francisco Gallardo-Chamizo, Sheila Pereira, Angela M. De los Santos, Angeles Rodriguez-Hernandez, Luis M. Marin, Jose M. Alamo, Francisco J Padillo16. Discovery and Development of RRx-001Jan Scicinski, Bryan Oronsky, Shoucheng Ning, Gary R Fanger, Susan J Knox, Mark BednarskiPart V: NO Meditated Alterations in Gene Products 17. Nitric Oxide Coagulation and CancerBenjamin A. Derman, Hau C. Kwaan, Malak Elbatarny, Maha Othman 18. Neutrosphyngomyelinase 2Bei Lei Sun and Bulent Mutus

About the Author

Dr. Benjamin Bonavida is a professor at UCLA's David Geffen School of Medicine for the Department of Microbiology, Immunology, & Molecular Genetics. His other appointments include being a member of the Department of Defense Congressionally Directed Medical Research Program, Member of the National Cancer Institute's SPORE Program, member of the International Scientific Advisory Board of the Israel Cancer Research Foundation, to name a few. He's currently a scientific reviewer for several journals and a member of editorial boards including Journal of Clinical Immunology, International Journal of Oncology, and Cancer Biotherapy & Radiopharmaceuticals.


"It describes the current perceptions on the role of NO. in cancer and a possible therapeutic application of NO. in the clinical practice. ... The book also presents several mechanisms of multiple effects and potential of NO. for therapeutic use under optimal conditions. It can be recommended to all readers who are interested in the pathogenesis and therapy of cancer." (Darina Slamenova, Neoplasma, Vol. 62 (6), 2015)

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