Part I: Molecular Cell Signaling by NO in cancer 1. Inflammation-associated Carcinogenesis Involved Interaction Between with iNOS/NO and WNT/beta-catenin Qiang Du and David A. Geller 2. NO and Genomic Stability Vasily A. Yakovlev 3. Targeting Hyponitroxia in Cancer Therapy Bryan Oronsky, Neil Oronsky, Michelle Lybeck, Gary Fanger, Jan Scicinski 4. Mechanism of NO-dependent Regulation of Invasion and Metastasis Aideen E Ryan, Amy J Burke, Francis J Giles, Francis J Sullivan, Sharon A Glynn 5. NO Role in Protumorigenesis and Hypoxia Lynne-Marie Postovit Part II: S-nitrosylation and cancer 6. Impacts of S-nitrosylation in Cancer Tysha N. Medeiros, Dana M. Jarigese, Melissa A. Edwards and Mark A. Brown 7. S-nitrosylation of Cancer Cells Ali Bettaieb, Stephanie Plenchette, Catherine Paul, Veronique Laurens, Sabrina Romagny, Jean-Francois Jeannin 8. Role of S-nitrosylation in Cancer Metastasis Sudjit Luanpitpong and Yon Rojanasakul Part III: Modulation of anti-tumor immune responses by NO 9. NO Immunity and Cancer Hermes J. Garban 10. Regulation of Anti-tumor Responses by NO Peter Siesjoe 11. NO Immune Modulation and Tumor Growth Naveena B. Janakiram and Chinthalapally V. Rao Part IV: Therapeutics and overcoming resistance 12. Role of NO in Chemo-immune Resistance Benjamin Bonavida 13. Emerging Role of NO-mediated Therapeutics Cian M. McCrudden and Helen O. McCarthy 14. PDT and NO Emilia Della Pietra and Valentina Rapozzi 15. Regulation of Cell Death by NO Jordi Muntane, Francisco Gallardo-Chamizo, Sheila Pereira, Angela M. De los Santos, Angeles Rodriguez-Hernandez, Luis M. Marin, Jose M. Alamo, Francisco J Padillo 16. Discovery and Development of RRx-001 Jan Scicinski, Bryan Oronsky, Shoucheng Ning, Gary R Fanger, Susan J Knox, Mark Bednarski Part V: NO Meditated Alterations in Gene Products 17. Nitric Oxide Coagulation and Cancer Benjamin A. Derman, Hau C. Kwaan, Malak Elbatarny, Maha Othman 18. Neutrosphyngomyelinase 2 Bei Lei Sun and Bulent Mutus
Dr. Benjamin Bonavida is a professor at UCLA's David Geffen School of Medicine for the Department of Microbiology, Immunology, & Molecular Genetics. His other appointments include being a member of the Department of Defense Congressionally Directed Medical Research Program, Member of the National Cancer Institute's SPORE Program, member of the International Scientific Advisory Board of the Israel Cancer Research Foundation, to name a few. He's currently a scientific reviewer for several journals and a member of editorial boards including Journal of Clinical Immunology, International Journal of Oncology, and Cancer Biotherapy & Radiopharmaceuticals.
"It describes the current perceptions on the role of NO. in cancer and a possible therapeutic application of NO. in the clinical practice. ... The book also presents several mechanisms of multiple effects and potential of NO. for therapeutic use under optimal conditions. It can be recommended to all readers who are interested in the pathogenesis and therapy of cancer." (Darina Slamenova, Neoplasma, Vol. 62 (6), 2015)