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Nitric Oxide in the Eye

The diverse roles in physiological function now attributed to nitric oxide include those it performs in the eye. This simple molecule has become the subject of increased attention among researchers and practitioners concerned with the eye. While most books in the field have concentrated on the pharmacology of NO in the central and peripheral nervous system or the cardiovascular system, the contents of this volume encompass all aspects of the eye and NO. The major sections of this text include reports of research in the mechanism of ocular hypertension and glaucoma (aqueous dynamics), ocular autonomic neurotransmission (ocular bloodflow), and the pathophysiology of uveitis. The final section contains three chapters on the role of NO specific to the retina.
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Table of Contents

I. Overview.- Nitric Oxide: Some New Concepts.- II. Aqueous Dynamics: Mechanisms of Ocular Hypertension and Glaucoma.- Contractility of Trabecular Meshwork and Ciliary Muscle: Modulation by the NO/cGMP System.- Origin and Function of Nitrergic Nerves in the Human Eye: Morphological Aspects.- III. Ocular Bloodflow: Ocular Autonomic Neurotransmission.- Cell Culture Studies of Oxygen, Nitric Oxide, and Retinal Pericytes' Contractile Tone.- Regulation of Retinal Arterial and Arteriolar Tone by Nitric Oxide Derived from Endothelium and Perivascular Nerve.- IV. The Uvea: Pathophysiology of Uveitis.- Nitric Oxide in the Iris Sphincter Muscle.- Role of Peroxynitrite in Photoreceptor Damage in Experimental Uveitis.- V. The Retina.- Regulation of Inducible Nitric Oxide Synthase in the Retina.- Neuronal Protection by Nitric Oxide-Related Species.- Nitric Oxide and Retinal Ischemia.

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