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Non-Alzheimer's and Atypical Dementia

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Table of Contents

Notes on contributors, vi 1 Introduction, 1 Michael D. Geschwind and Caroline Racine Belkoura 2 The multidisciplinary evaluation of the atypical dementia patient, 6 Michael D. Geschwind and Caroline Racine Belkoura 3 Atypical Alzheimer s disease, 17 Sharon J. Sha and Gil D. Rabinovici 4 Vascular cognitive impairment: Diagnosis and treatment, 30 Helena C. Chui and Liliana Ramirez-Gomez 5 Frontotemporal dementia, 49 David C. Perry and Howard J. Rosen 6 Lewy body dementias (DLB/PDD), 64 Carol F. Lippa and Katherine L. Possin 7 Corticobasal degeneration and progressive supranuclear palsy, 77 Suzee E. Lee and Bruce L. Miller 8 Repeat expansion diseases and dementia, 90 Praveen Dayalu, Roger L. Albin and Henry Paulson 9 Prion diseases and rapidly progressive dementias, 103 Leonel T. Takada and Michael D. Geschwind 10 Autoimmune dementias, 123 Andrew McKeon and Sean J. Pittock 11 Toxic and metabolic dementias, 134 Michelle Mattingly, Katie Osborn and Leon Prockop 12 Leukoencephalopathies/leukodystrophies, 150 Gregory M. Pastores and Swati A. Sathe 13 Infectious causes of dementia, 170 Cheryl A. Jay, Emily L. Ho and John Halperin 14 Rheumatologic and other autoimmune dementias, 186 Laura J. Julian and Christopher M. Filley 15 Comprehensive management of the patient with an atypical dementia, 202 Jennifer Merrilees, Cynthia Barton, Amy Kuo and Robin Ketelle Index, 215

About the Author

Michael Geschwind, MD PhD Dr. Geschwind received his MD and PhD in neuroscience through the National Institutes of Health-sponsored Medical Scientist Training Program at the Albert Einstein College of Medicine in New York. He completed his internship in internal medicine at the University of California, Los Angeles Medical Center, his neurology residency at the Johns Hopkins University School of Medicine in Baltimore and his fellowship in behavioral neurology at the UCSF Memory and Aging Center (MAC). He joined the Memory and Aging Center faculty in 2003 and is an Associate Professor of Neurology. Dr. Geschwind evaluates patients in the MAC new patient clinic and participates in the management and care for these patients in the MAC continuity clinic. He is active in the training of medical students and residents at UCSF. Dr. Geschwind teaches a national course and lectures, both nationally and internationally, on the assessment of rapidly progressive dementias, including human prion diseases. Dr. Geschwind's primary research interest is the assessment and treatment of rapidly progressive dementias, including prion diseases such as Creutzfeldt-Jakob disease (CJD). Dr. Geschwind helped establish an inpatient hospital program for the assessment of rapidly progressive dementias at UCSF, one of the first of its kind in the country. He ran the first ever US treatment study for CJD. He also has an active research interest in cognitive dysfunction in movement disorders, such as Huntington's disease, corticobasal degeneration (CBD), progressive supranuclear palsy (PSP) and other Parkinsonian dementias. Caroline Racine Belkoura, PhD Caroline Racine Belkoura received her BA in Psychology from Boston University, where she completed an honors thesis exploring visual-perceptual deficits in patients with stroke and traumatic brain injury. From 1997-1999 she worked as a research assistant with Dr. Dan Schacter at Harvard University on studies examining false memories in healthy aging. Dr. Racine Belkoura went on to obtain an MA and PhD in Clinical Psychology at Washington University in St. Louis, specializing in Neuropsychology and Aging. Her research at Washington University examined changes in frontal lobe function during healthy aging using both behavioral and neuroimaging methods (e.g., fMRI). She completed her clinical internship in Neuropsychology at Duke University in 2005 and afterward completed a two-year postdoctoral fellowship in Neuropsychology at the UCSF Memory and Aging Center. Since 2009, she has been an Assistant Professor in Neurological Surgery at UCSF. Currently, she evaluates patients with movement disorders who are undergoing workup for deep brain stimulation (DBS), as well as patients who are suspected of having atypical parkinsonian disorders. Her research focuses on cognitive and behavioural changes in the context of Parkinson s disease and related disorders, and how DBS affects cognition and mood.


"This deceptively slim volume, looking more like an atlas than a textbook, is actually a thorough, carefully organized, and well-referenced text on atypical dementias. Unlike most multiauthor medical textbooks, this one is divided into discrete chapters on individual syndromes, with overlap only in the general introductory chapter, a chapter on multidisciplinary evaluation, and a concluding chapter on management of patients with all types of atypical dementias. I would recommend the book both as useful background reading and as a ready reference when a neurologist, psychiatrist, or internist encounters a patient with any of the atypical dementias...Overall, the book is a very useful volume to have on hand when questions arise about a patient with cognitive issues, as well as a book to read from cover to cover. As I noted at the outset, the book is exceptionally cohesive, with all chapters similarly outlined and topics skillfully organized, thus minimizing repetition. I have also found several of Dr Geschwind s articles about atypical and rapidly progressive dementing illnesses to be very useful, especially proposing the mnemonic VITAMINS to outline the causes of dementiasto" (Cogn Behav Neurol 29:4 Dec-16)

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