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Prominent investigators and clinicians summarize in a balanced blend of fundamental science, basic research, experimental therapeutics, and early clinical experiences, what is known about oncogenes and oncogenesis, and describe how that knowledge can be used to treat the cancer. The contributors explain how, why, and under what conditions certain proteins acquire the ability to transform eukaryotic cells, and detail the crucial biological consequences of this oncogenic transformation, particularly for cellular mitogenesis, survival, differentiation, migration, proteolysis, or angiogenic competence. Their articles thoroughly explicate the premises, principles, techniques, and approaches to oncogene targeting in various types of human cancer by using signal transduction inhibitors, immunological targeting methods, and antisense gene therapy.
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Table of Contents

Part I. Basic Concepts in Oncogene Research Genetic Basis of Cancer Progression Susan J. Done and Jeremy A. Squire The Molecular Basis of Chromosomal Instability in Human Cancer Cells Daniel P. Cahill Signal Transduction Networks: Ras as a Paradigm Frank McCormick Oncogenic Receptor Tyrosine Kinases Mark H. Kirschbaum, Mina D. Marmor, and Yosef Yarden Ras-Mediated Deregulation of Gene Expression and Contribution to Oncogenesis Gretchen A. Murphy and Channing J. Der The Interplay Between Tumor Suppressor Genes and Oncogenes in Tumorigenesis Eric C. Holland Genetic Basis of Altered Responsiveness of Cancer Cells to Their Microenvironment Amato J. Giaccia Part II. The Functional Impact of Oncogene Expression on Cancer Cells-Therapeutic Implications Deregulation of Cell Cycle Progression by Oncogenic Transformation Marcelo L. Rodriguez-Puebla, Adrian M. Senderowicz, and Claudio J. Conti Oncogenes as Regulators of Cell Survival: The Role of Oncogenes and Tumor Suppressor Genes in the Induction of Resistance to Anoikis and Hypoxia Kirill Rosen and Jorge Filmus Oncogenes and Tumor Angiogenesis Janusz Rak and Robert S. Kerbel Oncogenes as Therapeutic Targets to Prevent Metastasis Ann F. Chambers and Hemanth J. Varghese The Impact of Oncogenes on Tumor Maintenance Senji Shirasawa and Takehiko Sasazuki Primary and Secondary Events in Oncogene-Driven Tumor Development: Lessons from Transgenic Model Systems Michaela Herzig and Gerhard Christofori Part III. Oncogenes as Targets for Anticancer Therapy In Vivo Targeting Oncogenes in Hematopoietic Malignancies Michael E. O'Dwyer and Brian J. Druker Clinical Evaluation of Agents Targeting Epidermal Growth Factor Receptor (EGFR) in Cancer Edward H. Lin and James L. Abbruzzese Inhibition of the HER-2/neu Oncogene: A Translational Research Model for the Development of Future Targeted Therapies Gottfried E. Konecny, Jane Arboleda, Dennis J. Slamon, and Mark Pegram Farnesyltransferase Inhibitors as Anticancer Agents Adrienne D. Cox Targeting Oncogenic Signaling Pathways in Human Astrocytomas Gelareh Zadeh and Abhijit Guha Targeting Oncogenes in Pediatric Malignancies Giannoula Klement and Robert S. Kerbel Inhibiting Signal Transduction as an Approach to Radiosensitizing Tumor Cells Eric J. Bernhard, Anjali K. Gupta, Elizabeth Cohen-Jonathan, Ruth J. Muschel, Stephen M. Hahn, and W. Gillies McKenna Oncogenes as Targets for Cancer Vaccines Samir N. Khleif and Joseph A. Lucci, III Bcl-2 Antisense Oligonucleotides Therapy for Cancer: Targeting the Mitochondria Finbarr E. Cotter and Dean A. Fennell Index

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"The book is well referenced, and readers will easily be able to locate primary literature for in-depth reading on specific topics. The figures and illustrations are extremely useful in summarizing complex topics that are discussed. In summary, this is an unique, well-organized, and timely presentation on a topic of high importance. People who will find this volume especially useful include students of tumor biology, basic scientists with an interest in novel therapeutic or translational research, and all clinicians who are involved in the diagnosis and treatment of patients with cancer." - Neuro-oncology "This book attempts to cover a vast and rapidly evolving field of research, both basic and clinical, and does so successfully by giving the reader a balanced mix of basic science, experimental therapeutics and clinical observations. Most chapters are richly illustrated and all have extensive lists of relevant references." - Medical Oncology "...this book will be useful not only to those just starting their research careers, including graduate and medical students, but also to those who have been involved in the field of cancer biology and treatment for a number of years, including seasoned scientists and clinicians." -Doody's Health Sciences Book Review Journal

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