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Oxford Desk Reference


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Table of Contents

1 Principles of Endocrinology 1.1: Hormones, Receptors and signalling 1.2: Hormone measurements: Assays 1.3: Hormone measurements: Hormone Binding Proteins 1.4: Hormone measurements: Biological Matrices for Hormone Measurement 1.5: Autoimmunity and the Endocrine System 1.6: Genetic Endocrine Disorders 1.7: Geographic and Ethnic Variation in Endocrine Disorders 2 Thyroid Hormone Metabolism 2.1: Anatomy and physiology 2.2: Thyroid Investigations 2.3: Imaging and Localisation of the Thyroid 2.4: Approach to the assessment of disorders of thyroid hormone homeostasis 2.5: Hyperthyroidism 2.6: Thyroiditis 2.7: Hypothyroidism 2.8: Thyroid Nodules and Cancer 3 Pituitary Gland 3.1: Anatomy and Physiology 3.2: Genetic testing for pituitary adenomas 3.3: Pituitary Imaging and Localisation 3.4: Approach to the assessment of disorders of pituitary hormone homeostasis 3.5: Prolactinomas 3.6: Acromegaly 3.7: Cushing s disease 3.8: Non-Functioning Pituitary Tumours 3.9: Gonadotroph adenomas 3.10: Thyrotrophinomas 3.11: Pituitary Incidentalomas 3.12: Pituitary Carcinoma 3.13: Craniopharyngioma and Perisellar Cysts 3.14: Pituitary Apoplexy 3.15: Surgical Treatment 3.16: Pituitary Radiotherapy 3.17: Parasellar Pituitary Conditions 4 Posterior Pituitary Gland 4.1: Diabetes Insipidus 4.2: Hyponatraemia 4.3: Syndrome of inappropriate ADH (SIADH) 4.4: Disorders of Hypothalamic Function 5 Pineal Gland 5.1: Melatonin and Pineal Tumours 6 Adrenal Gland 6.1: Adrenal Anatomy and Physiology 6.2: Laboratory Investigation of Adrenal Disease 6.3: Imaging the Adrenal Glands 6.4: Primary Hyperaldosteronism 6.5: Mineralocorticoid Hypertension 6.6: Liddle syndrome 6.7: Bartter and Gitelman syndromes 6.8: Cushing s and Subclinical Cushing s Syndrome 6..9: Adrenal incidentalomas 6.1: Adrenal carcinoma 6.11: Addison s disease 6.12: Glucocorticoid replacement 6.13: Autoimmune Polyglandular Syndrome (APS) 6.14: Phaeochromocytoma 6.15: Adrenal surgery 7 Female Hormone Metabolism 7.1: Anatomy and Physiology 7.2: Investigation 7.3: Imaging of Ovarian Tumours 7.4: Polycystic Ovary Syndrome 7.5: Congenital Adrenal Hyperplasia 7.6: Androgen Secreting Tumours 7.7: Primary Ovarian Failure and Premature Ovarian Insufficiency 7.8: Turner syndrome 7.9: Approach to the assessment of disorders of menstrual function 8 Male Hormone Metabolism 8.1: Anatomy and Physiology 8.2: Investigation 8.3: Primary Hypogonadism 8.4: Secondary Hypogonadism 8.5: Erectile Dysfunction 8.6: Gynaecomastia 9 Disorders of Gender and Fertility 9.1: Disorders of sex development (DSD) 9.2: Gender Dysphoria 9.3: Male and Female infertility 10 Endocrine Disorders in Pregnancy 10.1: Thyroid disorders in pregnancy 10.2: Adrenal Disease in pregnancy 10.3: Pituitary Adenomas in Pregnancy 11 Mineral Metabolism 11.1: Anatomy and physiology 11.2: Investigations 11.3: Hypercalcaemia 11.4: Inherited Primary Hyperparathyroidism 11.5: Hypocalcaemia 11.6: Disorders of phosphate homeostasis: Hypophosphataemia including X-linked hypophosphataemic rickets 11.7: Disorders of phosphate homeostasis: Hyperphosphataemia, including tumoral calcinosis 11.8: Disorders of phosphate homeostasis: Chronic kidney disease mineral and bone disorder (CKD-MBD) 12 Bone 12.1: Anatomy and physiology 12.2: Investigation of metabolic bone disease: Biochemical markers of bone turnover 12.3: Investigation of metabolic bone disease: Dual energy X-ray absorptiometry 12.4: Investigation of metabolic bone disease: Plain radiography 12.5: Investigation of metabolic bone disease: Bone biopsy 12.6: Osteoporosis 12.7: Focal Bone Disorders 12.8: Osteogenesis imperfecta 12.9: Sclerosing bone disorders 12.10: Fibrodysplasia ossificans progressiva 13 Endocrine Oncology and Neuroendocrine Disorders 13.1: General introduction 13.2: Neuroendocrine imaging 13.3: Carcinoids 13.4: Insulinoma 13.5: Gastrinomas 13.6: Glucagonomas 13.7: VIPomas 13.8: Somatostatinomas 13.9: Ectopic Hormone Production 13.10: Endocrine Function Following Chemotherapy and Radiotherapy 14 Inherited Endocrine Syndromes and Multiple Endocrine Neoplasia 14.1: McCune-Albright syndrome 14.2: Endocrine Tumours in Neurofibromatosis type 1 14.3: Von-Hippel Lindau Disease 14.4: Carney Complex 14.5: Cowden syndrome 14.6: POEMS syndrome 14.7: MEN1 14.8: MEN2 15 Endocrinology of Metabolism 15.1: Hypoglycaemia 15.2: Obesity 15.3: Eating disorders and starvation 15.4: Sports and endocrinology 15.5: Possible Endocrine Syndromes 16 Hormone Resistance Syndromes 16.1: Resistance to thyroid hormone 16.2: Androgen Insensitivity Syndromes 16.3: Primary Generalised Gluco-corticoid resistance or Chrousos Syndrome 16.4: Syndromes of hormone resistance: ACTH 16.5: Aldosterone resistance 17 Endocrinology of Different Age-Groups 17.1: Adolescents in Endocrinology 17.2: Endocrinology and Ageing 18 Endocrine Investigation, Nursing And Dietetics 18.1: Laboratory investigations in Endocrine Disorders 18.2: The Role of the Endocrine Specialist Nurse 18.3: Endocrine dietetics 19 Patient Advice and Reference 19.1: Diagrams for explanation to patients 19.2: Bone and mineral metabolism 19.3: Clinical Genetics 19.4: Patient support and information resource 20 Speedy Reference 20.1: Indications for treatment of sub-clinical hyperthyroidism 20.2: Differentiated thyroid cancer follow-up 20.3: Indications for GH treatment 20.4: Follow-up of Pituitary Tumours 20.5: Management of Osteoporosis 20.6: Autoimmune Polyglandular Syndromes (APS) 20.7: Investigations in patients with existing autoimmune endocrine diseases 20.8: Hyperglycaemia 20.9: Hyperlipidaemia 20.10: Hypertension 21 Medicolegal Aspects 21.1: Risk explanation 21.2: DVLA regulations

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Highly Commended in the Internal Medicine category at the BMA Book Awards 2019

About the Author

Dr Helen Turner (MA (Cantab.) MD FRCP LLB Hons) trained at Cambridge University followed by St Bartholomews Hospital, and has been a Consultant Endocrinologist in Oxford since 2000. Her MD research was angiogenesis in endocrine tumours. She has written many research papers and her main clinical and research interests are Turner Syndrome and the Management of Thyroid eye disease. She initiated and edits the successful Oxford Handbook of Endocrinology which is now in its third edition. Richard Eastell qualified in medicine from Edinburgh in 1977. He trained in endocrinology in Edinburgh, Northwick Park and at the Mayo Clinic (Dr B L Riggs). He leads a research group on the pathogenesis, diagnosis and treatment of osteoporosis; of particular note is his contribution to the use of bone turnover markers and the development of treatments for osteoporosis. He was the first European elected to the Council of ASBMR and was its 2013 meeting clinical co-chair. His work has recently been recognised by the Ian MacIntyre Medal (2011), Philippe Bordier Award (2012) (European Calcified Tissue Society), Frederic C Bartter Award 2014 (American Society for Bone and Mineral Research) and IBIS Team Member awarded 2014 Translational Cancer Research Prize, Cancer Research UK, 2014. Ashley Grossman graduated in Psychology and Social Anthropology from the University of London, and then in Neurosciences and eventually Medicine from University College London: he is Professor of Endocrinology and Fellow of Green-Templeton College at the University of Oxford, Professor of Neuroendocrinology at Barts and the London School of Medicine, and Consultant NET Endocrinologist at the Royal Free Hospital, London. His current interests revolve around the pathogenesis of endocrine tumours including adrenal, pituitary and neuroendocrine tumours. He is a Fellow of the Academy of Medical Sciences, and author or co-author of some 850 original articles and reviews.


This is an excellent book for its selected audience ... I will certainly recommend this to my colleagues and trainees. * BMA reviewing panel, BMA Medical Book Awards 2019 *
Endocrinology is not always the easiest subject to study or understand but this book makes life a lot easier for the reader[it] is an excellent book which ... covers its subject matter with authority and depth. * Dr Harry Brown MBChB, Glycosmedia *

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