Table of Contents

I. Oxidative Stress and Disease
1. Oxidative stress causes
2. Historical perspective
3. Chemicals and chemical mixtures
4. Particles and fibers
5. Air pollution
6. Alcohol, tobacco and recreational drug use
7. Radiation
8. Chronic inflammation
9. Chronic Trauma
10. Dietary choices
11. Sleep deprivation
12. Hot and cold Environmental temperature extremes
13. Pre-existing disease
14. Pharmaceutical drugs
15. Chronic psychological stress
16. Genetic and epigenetic factors

II. Mechanism of Disease Onset
17. Disease hallmarks and biomarkers
18. Disease clusters
19. Disease co-morbidities
20. Free radical attack on DA
21. Free radical attack on proteins
22. Free radical attack on lipophilic cell membranes
23. Free radical stability factors
24. Free radical attack on mitochondria and energy production
25. Immune System role
26. Obesity-oxidative stress-disease triangle: Impact of obesity oxidative stress and disease
27. Acute versus chronic oxidative stress
28. Age and late onset disease
29. Total oxidative stress

III. Oxidative Stress Index and Its Applications
30. Oxidative stress index and its premise
31. Predicting likelihood of disease onset
32. Identifying primary causes of specific diseases
33. Oxidative Stress Index as a public health survey instrument
34. Adverse drug reaction prediction
35. Predicting severity of COVID-19 and other diseases
36. Oxidative Stress Index as a virtual diagnostic tool
37. Disease prevention
38. Future applications

About the Author

Dr. Harold I. Zeliger holds a PhD in organic chemistry and has been a professor of chemistry and environmental science. He is a Certified Professional Chemist, a Board- Certified Forensic Examiner, and an EPA Certified Laboratory Director. Dr. Zeliger is the author of 51 technical publications, including basic research journal articles and patents. In his more than 40 years in the Chemical Process Industry, he has personally developed many industrial and consumer chemical products, designed chemical product warning labels and written Material Safety Data Sheets for toxic and flammable chemicals. Dr. Zeliger has investigated hundreds of toxic chemical exposures, environmental spills and discharges, chemical fires and explosions nationally and internationally. He has served repeatedly as an expert witness for both plaintiffs and defendants in chemical product, process, toxic exposure, environmental, flammable, intellectual property and subrogation claims. Dr. Zeliger has provided services for numerous forensic examinations, technology transfer and due diligence investigations. Dr. Zeliger’s research is in the area of chemical toxicology. His published work includes papers on the toxic effects of chemical mixtures and chemical causes of cancer clusters and two editions of Human Toxicology of Chemical Mixtures, Second Edition.