Part 1: 1. Introduction Part 2: Background Information 2. Background of The Animals and the Rat Colony Part 3: Results and Discussion 3. Longevity Studies 4. Age-Associated Pathology 5. Evaluation of the Age-Associated Risk for Multiple Tumors and Tumor Metastases in Aging Rats 6. Comparisons of the Incidence of Lesions in Rats that Dies Spontaneously to Those Killed at Different Ages 7. Spontaneously Occurring Posterior Paralysis: Further Studies to Determine the Age of Onset and Progression of The Syndrome Part 4: Greenall Discussion 8. The F1 Hybrid: Comparison with the Parent Strains 9. Summary of Potential Models of Aging and Carcinogenesis Research Using BN/Bi, WAG/Rij, and (WAG X BN) F1 Rats 10. Importance of Life Span Longevity and Pathology Data from Rats 11. The Onset of Age-Associated Lesions and Aging in Rats

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