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Preface; 1. Target: a useful model; 2. Methods of biochemical systems theory; 3. A model of citric acid production in the mold Aspergillus niger; 4. Optimization methods; 5. Optimization of biochemical systems; 6. Optimization of citric acid production in Aspergillus niger; 7. Maximization of ethanol and carbohydrate production in Saccharomyces cerevisiae; 8. Conclusions; Author index; Subject index.