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Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition


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Table of Contents

Peptide Synthesis
Knud J. Jensen
Protein Expression
Nanni Din
Protein Purification
Lars Hovgaard, Lars Skriver, and Sven Frokjaer
Characterization of Therapeutic Peptides and Proteins
Marco van de Weert and Tudor Arvinte
Chemical Pathways of Peptide and Protein Degradation
Teruna J. Siahaan and Christian Schoeneich
Physical Instability of Peptides and Proteins
Marco van de Weert and Theodore W. Randolph
Peptide and Protein Derivatives
Kristian Stromgaard and Thomas Hoeg-Jensen
Peptides and Proteins as Parenteral Solutions
Michael J. Akers and Michael R. DeFelippis
Peptides and Proteins as Parenteral Suspensions: An Overview of Design, Development, and Manufacturing Considerations
Michael R. DeFelippis and Michael J. Akers
Rational Design of Solid Protein Formulations
Bingquan (Stuart) Wang and Michael J. Pikal
Peptide and Protein Drug Delivery Systems for Nonparenteral Routes of Administration
Ulrik Lytt Rahbek, Frantisek Hubalek, and Simon Bjerregaard
Immunogenicity of Therapeutic Proteins
Grzegorz Kijanka, Wim Jiskoot, Melody Sauerborn, Huub Schellekens, and Vera Brinks
Biosimulation of Peptides and Proteins
Tue Soeborg, Christian Hove Rasmussen, Erik Mosekilde, and Morten Colding-Jorgensen
Registration of Peptides and Proteins
Niamh Kinsella

About the Author

Lars Rovgaard is Principal Scientist for NovoNordisk A/S and a Professor at Copenhagen University, Denmark. Sven Frokjaer is Dean of the Pharmaceutical Sciences Faculty at the University of Copenhagen Denmark. Marco van de Weert is an Associate Professor of Pharmaceutics and Analytical Chemistry at the University of Copenhagen.

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