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Pharmacology of Neurotransmitter Release

It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. In the second part of the book, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process.
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Table of Contents

Neurotransmitter Release.- Pharmacology of Neurotransmitter Release: Measuring Exocytosis.- Presynaptic Calcium Channels: Structure, Regulators, and Blockers.- Pharmacology of Neurotransmitter Transport into Secretory Vesicles.- Core Proteins of the Secretory Machinery.- Presynaptic Neurotoxins with Enzymatic Activities.- ?-Latrotoxin and Its Receptors.- Presynaptic Signaling by Heterotrimeric G-Proteins.- Presynaptic Metabotropic Receptors for Acetylcholine and Adrenaline/Noradrenaline.- Presynaptic Receptors for Dopamine, Histamine, and Serotonin.- Presynaptic Adenosine and P2Y Receptors.- Presynaptic Metabotropic Glutamate and GABA B Receptors.- Presynaptic Neuropeptide Receptors.- Presynaptic Modulation by Endocannabinoids.- Presynaptic lonotropic Receptors.- NO/cGMP-Dependent Modulation of Synaptic Transmission.- Therapeutic Use of Release-Modifying Drugs.

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