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Platform Technologies in Drug Discovery and Validation

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Table of Contents

1. DNA-Encoded Library Technology: A Brief Guide to Its Evolution and Impact on Drug Discovery Robert A. Goodnow Jr. and Christopher P. Davie 2. The Chemistry of Oligonucleotide Delivery David B. Rozema 3. CRISPR-Cas9 for Drug Discovery in Oncology Sylvie M. Guichard 4. Recent Advances of Microfluidics Technologies in the Field of Medicinal Chemistry Laszlo UErge, Jesus Alcazar, Lena Huck and Gyoergy Dorman 5. High-Throughput Screening Mary Jo Wildey, Anders Haunso, Matthew Tudor, Maria Webb and Jonathan H. Connick 6. Kinase-Centric Computational Drug Development Albert J. Kooistra and Andrea Volkamer 7. Free Energy Calculation Guided Virtual Screening of Synthetically Feasible Ligand R-Group and Scaffold Modifications: An Emerging Paradigm for Lead Optimization Robert Abel and Sathesh Bhat 8. Phenotypic Screening Alleyn T. Plowright and Lauren Drowley 9. Targeted Protein Degradation Nello Mainolfi and Tim Rasmusson 10. Chemical Biology in Drug Discovery M. Paola Castaldi, Andrea Zuhl, Piero Ricchiuto and J. Adam Hendricks 11. Fragment-Based Lead Discovery Ben J. Davis and Stephen D. Roughley 12. Antibody-Drug Conjugates Amit Kumar, Jason White, R. James Christie, Nazzareno Dimasi and Changshou Gao 13. Antibody-Recruiting Small Molecules: Synthetic Constructs as Immunotherapeutics Patrick J. McEnaney, Christopher G. Parker and Andrew X. Zhang 14. A Decade of Deuteration in Medicinal Chemistry Julie F. Liu, Scott L. Harbeson, Christopher L. Brummel, Roger Tung, Robert Silverman and Dario Doller 15. From Natural Peptides to Market Claudio D. Schteingart and Jolene L. Lau

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Provides a single, rich volume that summaries a broad spectrum of expertise relevant to the field of drug discovery and validation

About the Author

Robert A. Goodnow, Jr. is currently Vice President, Chemistry Innovation at Pharmaron, Inc in Boston, MA. He completed a Ph.D. in bioorganic chemistry at Columbia University, New York, USA, followed by postdoctoral training at Princeton University, New Jersey, USA. He has worked at Roche and AstraZeneca, focusing on new lead and target discovery as well as implementing chemistry technologies in support of early drug discovery. He is the editor and author of The Handbook of DNA-Encoded Chemistry, which was published in 2014 by Wiley.

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