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Porphyrin Photosensitization

This book contains contributions from participants at a Porphyrin Photosensitization Workshop held in Washington DC on 28-29 September, 1981. There had been several prior such gatherings during 1979 and 1980, but the 1981 meeting was the most extensive to date with almost 200 attending. These periodic meetings are designed to enable workers in the field to exchange information and learn of recent develop- ments. The Workshop was supported by PHS grant CA 31188 awarded by the National Cancer Institute, DHHS. Additional funds from Coherent Inc. [Laser Division], Palo Alto, con- tributed to the success of this meeting as did the many ex- cellent presentations and discussions. Preparation of camera-ready copy from submitted manu- scripts was carried out via the Textedit computer program by Glenn Cummings, Amanda Cummings and David Kessel. Respon- sibility for final manuscript preparation rests with the editors. David Kessel Thomas J. Dougherty CONTENTS INTRODUCTION D. Kessel and T.J. Dougherty. . * * . * . * . * * 1 PHOTORADIATION THERAPY - CLINICAL AND DRUG ADVANCES 3 T.J. Dougherty, D.G. Boyle, K.R. Weishaupt, B.A. Henderson, W.R. Potter, D.A. Bellnier and K.E. Wityk INTRA-ABDOMINAL APPLICATIONS OF HEMATOPORPHYRIN 15 PHOTORADIATION THERAPY . * ...* . * * .
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Table of Contents

Photoradiation Therapy - Clinical and Drug Advances.- Intra-Abdominal Applications of Hematoporphyrin Photoradiation Therapy.- Effectiveness of HPD and Radiation Therapy in Lung Cancer.- Hematoporphyrin Derivative in the Diagnosis and Treatment of Lung Cancer.- Laser Photoradiation Therapy of Recurrent Human Breast Cancer and Cancer of the Head and Neck.- HPD Photoradiation Therapy for Cancer at Kingston and Hamilton.- Light Dosimetry in Tissue: Application to Photoradiation Therapy.- Thermal Distribution During Photoradiation Therapy.- Photobiologic Considerations in Photoradiation Therapy.- Preclinical Evaluation of Hematoporphyrin Derivative for the Treatment of Intraocular Tumors: A Preliminary Report.- Porphyrin Localizing Phenomena.- Aspects of the Cellular Uptake and Retention of Hematoporphyrin Derivative and Their Correlation with the Biological Response to Prt in Vitro.- Cellular Uptake, Excretion and Localization of Hematoporphyrin Derivative.- Studies of HPD: Chemical Composition and in Vitro Photosensitization.- Hematoporphyrin Derivative. Chemical Composition, Photochemical and Photosensitizing Properties.- A Preliminary Comparison of the Photosensitizing Properties of Porphyrins in Aqueous Solution and Liposomal Systems.- Factors Governing the Mechanism and Efficiency of Porphyrin-Sensitized Photooxidations in Homogeneous Solutions and Organized Media.- Photodynamic Action of Protoporphyrin on Resealed Erythrocyte Membranes: Mechanisms of Release of Trapped Markers.- Photodynamic Membrane Damage.- HPD - A Study of its Components and Their Properties.- The Analysis of Hematoporphyrin Derivative.- Potential use of Radiolabelled Porphyrins for Tumor Scanning.- Excited State Interactions of Protoporphyrin IX and Related Porphyrins with Molecular Oxygen in Solutions and in Organized Assemblies.

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