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Power Analysis of Trials with Multilevel Data
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Table of Contents

List of figures. List of tables. Preface. Introduction. Multilevel statistical models. Concepts of statistical power analysis. Cluster randomized trials. Improving statistical power in cluster randomized trials. Multisite trials. Pseudo cluster randomized trials. Individually randomized group treatment trials. Longitudinal intervention studies. Extensions: three levels of nesting and factorial designs. The problem of unknown intraclass correlation coefficients. Computer software for power calculations. References. Author Index. Subject Index.

About the Author

Mirjam Moerbeek is an associate professor at Utrecht University, the Netherlands. She obtained her master’s degree (cum laude) in biometrics from Wageningen Agricultural University in 1996 and her PhD in applied statistics from Maastricht University in 2000. She has received prestigious research grants from the Netherlands’ Organisation for Scientific Research (NWO) as well as grants to hire PhD students. Her research interests are statistical power analysis and optimal experimental design, especially for hierarchical and survival data. She was involved in organizing a colloquium and class on cost-efficient and optimal designs for the Royal Netherlands Academy of Arts and Sciences (KNAW) and is a joint organizer of the biennial International Conference on Multilevel Analysis.

Steven Teerenstra received his MSc and PhD in mathematics at Radboud University in 1996 and 2004, respectively, as well as his MSc in theoretical physics in 2006. He is currently a biostatistician at Radboud University Nijmegen Medical Center, involved in research, consultation and conduct of cluster randomized trials. He is appointed assessor of statistics and methodology at the Dutch Medicines Evaluation Board and a member of the Biostatistics Working Party at the European Medicines Agency.

Reviews

"I enjoyed reviewing the new CRC Press/Chapman Hall book entitled Power Analysis of Trials with Multilevel Data, by Mirjam Moerbeek and Steven Teerenstra. This book addresses a critical need in the scientific community for a well-organized, easily accessible guide to performing power analysis and computing required sample sizes for randomized trials embedded in multilevel study designs, where observations of interest are nested within higher level units (e.g. patients within clinics or repeated measures on participants). …
This book effectively compiles all the published literature on this specialized topic, putting it in one place for researchers who design these types of studies and could benefit from a concise and practical resource on this important aspect of study design. The two Dutch authors are experts in this area and are very well-equipped to provide more general education and practical advice on this topic. Multilevel study designs in which power analysis methods for independent observations do not apply are quite common, but no prior books have attempted to organize all the possible power analysis approaches for these types of studies into a single reference. …
In sum, this will be a very useful book for researchers, statisticians, and consultants responsible for designing various types of randomized trials in multilevel settings. My minor quibbles are far outweighed by the important contributions that this single resource on power analysis in multilevel designs will make to the scientific community."
—Brady T. West, University of Michigan, Biometrical Journal, May 2017"…the appearance of the book, Power Analysis of Trials with Multilevel Data, is well timed…Another nice feature of the book is the example power analyses that conclude most chapters (and sometimes appear earlier in chapters as well). The authors have done a very good job finding articles in the literature that use a particular design, extracting relevant parameters from those articles, and then illustrating how to use those parameters to plan a replication study…I think this book deserves a place on the bookshelf of both researchers who plan experimental studies and statisticians who advise them."
—Christopher H. Rhoads, University of Connecticut, The American Statistician, November 2016

"I enjoyed reviewing the new CRC Press/Chapman Hall book entitled Power Analysis of Trials with Multilevel Data, by Mirjam Moerbeek and Steven Teerenstra. This book addresses a critical need in the scientific community for a well-organized, easily accessible guide to performing power analysis and computing required sample sizes for randomized trials embedded in multilevel study designs, where observations of interest are nested within higher level units (e.g. patients within clinics or repeated measures on participants). …
This book effectively compiles all the published literature on this specialized topic, putting it in one place for researchers who design these types of studies and could benefit from a concise and practical resource on this important aspect of study design. The two Dutch authors are experts in this area and are very well-equipped to provide more general education and practical advice on this topic. Multilevel study designs in which power analysis methods for independent observations do not apply are quite common, but no prior books have attempted to organize all the possible power analysis approaches for these types of studies into a single reference. …
In sum, this will be a very useful book for researchers, statisticians, and consultants responsible for designing various types of randomized trials in multilevel settings. My minor quibbles are far outweighed by the important contributions that this single resource on power analysis in multilevel designs will make to the scientific community."
—Brady T. West, University of Michigan, Biometrical Journal, May 2017"…the appearance of the book, Power Analysis of Trials with Multilevel Data, is well timed…Another nice feature of the book is the example power analyses that conclude most chapters (and sometimes appear earlier in chapters as well). The authors have done a very good job finding articles in the literature that use a particular design, extracting relevant parameters from those articles, and then illustrating how to use those parameters to plan a replication study…I think this book deserves a place on the bookshelf of both researchers who plan experimental studies and statisticians who advise them."
—Christopher H. Rhoads, University of Connecticut, The American Statistician, November 2016

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