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Principles of Endocrine Pharmacology

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Table of Contents

1. Introduction and General Mechanisms of Hormonal Actions.- 1.1. History and Scope of Endocrine Pharmacology.- 1.2. General Concepts of Hormone Actions.- 1.2.1. Hormone Receptor/Acceptors.- 1.2.2. Hormone Substitutes.- 1.2.3. Hormone Antagonists.- 1.2.4. Hormone Synthesis Inhibitors.- 1.3. Hormonal Feedback Systems.- Recommended Readings.- 2. Pharmacology of Adenohypophyseal Hormones.- 2.1. Factors Modifying Adenohypophyseal Secretion: Hypophysiotrophic Hormones.- 2.1.1. CRH.- 2.1.2. TRH.- 2.1.3. LH/FSH-RH (GnRH).- 2.1.4. GH-RF and GH-IF (SRIF).- 2.1.5. PRF and PIF.- 2.1.6. MRF and MIF.- 2.2. Pharmacology of Anterior Pituitary Hormones.- 2.2.1. TSH.- 2.2.2. STH or GH.- 2.2.3. ACTH.- 2.2.4. FSH/LH.- 2.2.5. PRL.- Recommended Readings.- 3. Posterior Pituitary Hormones, Oxytocics, and Prostaglandins.- 3.1. Posterior Pituitary Hormones.- 3.1.1. History.- 3.1.2. Synthesis, Transport, and Release.- 3.1.3. Antidiuretic Hormone.- 3.1.4. Oxytocin.- 3.2. Ergot Alkaloids.- 3.2.1. Chemistry.- 3.2.2. Mechanism of Action and Biochemical Effects.- 3.2.3. Therapeutic Uses and Preparations.- 3.2.4. Adverse Effects.- 3.3. Prostaglandins: Reproductive Actions.- 3.3.1. Chemistry.- 3.3.2. Mechanism of Action and Biochemical Effects.- 3.3.3. Therapeutic Uses and Preparations.- 3.3.4. Adverse Effects.- 3.3.5. Prostaglandin Inhibitors.- 3.3.6. Uterine Relaxants.- Recommended Readings.- 4. Thyroid and Antithyroidal Drugs.- 4.1. Thyroid.- 4.1.1. History.- 4.1.2. Central Regulation of the Thyroid.- 4.1.3. Chemistry, Biosynthesis, Secretion, and Metabolism.- 4.1.4. Thyroid Hormone Receptors.- 4.1.5. Biochemical Actions.- 4.1.6. Management of Hypothyroidal States.- 4.1.7. Therapeutic Uses and Preparations.- 4.1.8. Adverse Effects.- 4.2. Antithyroidal Agents.- 4.2.1. Thyrotoxicosis (Hyperthyroidism).- 4.2.2. Drugs Used in the Management of Thyrotoxicosis.- 4.3. Drug Interactions and Thyroid Function Tests.- Recommended Readings.- 5. Parathyroid Hormone and Calcitonin.- 5.1. Introduction.- 5.2. History.- 5.3. Parathyroid Hormone.- 5.3.1. Chemistry.- 5.3.2. Biosynthesis, Secretion, and Metabolism.- 5.3.3. Mechanism of Action.- 5.3.4. Physiological and Pharmacological Actions.- 5.3.5. Preparations.- 5.3.6. Therapeutic Uses.- 5.3.7. Adverse Effects.- 5.4. Calcitonin.- 5.4.1. Chemistry.- 5.4.2. Biosynthesis, Secretion, and Metabolism.- 5.4.3. Mechanism of Action.- 5.4.4. Physiological and Pharmacological Actions.- 5.4.5. Preparations.- 5.4.6. Therapeutic Uses.- 5.4.7. Adverse Effects.- Recommended Readings.- 6. Androgenic and Anabolic Steroids.- 6.1. Introduction.- 6.2. History.- 6.3. Chemistry.- 6.4. Biosynthesis, Secretion, and Metabolism.- 6.5. Mechanism of Action.- 6.6. Physiological and Pharmacological Actions of Androgens.- 6.7. Preparations.- 6.8. Therapeutic Uses.- 6.9. Adverse Effects.- 6.10. Weak or Impeded Androgens.- 6.11. Androgen Antagonists.- Recommended Readings.- 7. Estrogens and Antiestrogenic Drugs.- 7.1. Estrogens.- 7.1.1. Introduction.- 7.1.2. History.- 7.1.3. Chemistry.- 7.1.4. Biosynthesis, Secretion, and Metabolism.- 7.1.5. Mechanism of Action.- 7.1.6. Physiological Actions.- 7.1.7. Therapeutic Uses.- 7.1.8. Preparations.- 7.1.9. Adverse Effects.- 7.2. Antiestrogens.- 7.2.1. Clomiphene.- 7.2.2. Tamoxifen.- Recommended Readings.- 8. Progestins and Oral Contraceptives.- 8.1. Progestins.- 8.1.1. Introduction.- 8.1.2. History.- 8.1.3. Chemistry.- 8.1.4. Biosynthesis, Secretion, and Metabolism.- 8.1.5. Mechanism of Action.- 8.1.6. Physiological Effects.- 8.1.7. Therapeutic Uses.- 8.1.8. Preparations.- 8.1.9. Adverse Effects.- 8.2. Oral Contraceptives.- 8.2.1. Preparations.- 8.2.2. Mechanism of Action.- 8.2.3. Adverse Effects.- Recommended Readings.- 9. Adrenocorticosteroid Drugs.- 9.1. Introduction.- 9.2. History.- 9.3. Chemistry.- 9.4. Biosynthesis, Secretion, and Metabolism.- 9.5. Mechanism of Action.- 9.6. Physiological and Pharmacological Actions.- 9.7. Preparations.- 9.8. Therapeutic Uses.- 9.9. Adverse Effects.- 9.10. Inhibitors of Adrenocortical Steroid Biosynthesis.- Recommended Readings.- 10. Insulin and Oral Hypoglycemic Agents.- 10.1. Insulin.- 10.1.1. History of Diabetes Mellitus.- 10.1.2. Chemistry of Insulin.- 10.1.3. Secretion and Metabolism.- 10.1.4. General Biochemical Events and Actions.- 10.1.5. Insulin Receptors.- 10.1.6. Receptor-Mediated Internalization.- 10.1.7. Factors Affecting Insulin and Insulin Resistance.- 10.1.8. Uses and Preparations.- 10.1.9. Adverse Effects.- 10.2. Oral Hypoglycemic Agents.- 10.2.1. Sulfonylureas.- 10.2.2. Biguanides.- 10.3. Glucagon.- 10.4. Somatostatin.- 10.5. Nonhormonal Hyperglycemic Agents.- Recommended Readings.- 11. Effects of Drugs on the Endocrine System.- 11.1. Introduction.- 11.2. Basic Mechanisms of Drug-Hormone Interactions.- 11.3. Effects of Drugs on Adenohypophyseal Function.- 11.4. Effects of Drugs on Neurohypophyseal Function.- 11.5. Effects of Drugs on Lactation and Their Presence in Milk.- 11.6. Effects of Drugs on Hormone Transport.- 11.7. Effects of Drugs on Steroidogenesis.- 11.8. Effects of Drugs on Gonadal Function.- 11.9. Effects of Drugs on Pancreatic Function.- 11.10. Effects of Drugs on Thyroid Function.- 11.11. Effects of Drugs on Laboratory Analyses.- Recommended Readings.

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