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Protein Methylation

This significant volume provides reviews on protein methylation reactions which occur ubiquitously in nature. Written in a comprehensive style, this work covers knowledge on the natural occurrence of methylated amino acids, their chemical synthesis, plus the enzymology, biological regulator, and biological significance of free methylated amino acids. It also includes various specific biological systems where posttranslational methylation reactions have been demonstrated. This text is unique because the chapters are critically reviewed by authorities in each respective field. This well-written volume is an excellent reference to researchers as well as graduate students interested in post-synthetic modifications of macromolecules.
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Table of Contents

The Occurrence and Analysis of Methylated Amino Acids. Reevaluation of the Enzymology of Protein Methylation. Calmodulin and Protein Methylation. Cytochrome c Methylation. Protein-Arginine Methylation: Myelin Basic Protein as a Model. Amino Acid Sequence of Arginine Methylation Sites. Histone Methylation and Gene Regulation. Post-translational Methylation of Histones and Heat Shock Proteins in Response to Heat and Chemical Stresses. Ribosomal Protein Methylation. The Function and Enzymology of Protein D-Aspartyl/L-Isoaspartyl Methyltransferases in Eukaryotic and Prokaryotic Cells. Identities, Origins, and Metabolic Rates of the Substrates for Eukaryotic Protein Carboxyl Methyltransferases. Protein Carboxylmethylation in Nervous Tissues. Protein Methylesterase from Mammals. Chemotactic Methylation in Bacillus subtilis. The Chemotaxis-Specific Methylesterase of Enteric Bacteria. Role of Protein Carboxyl Methylation in Bacterial Chemotaxis. Self-Methylation by Suicide DNA Repair Enzymes. Natural and Synthetic Analogues of S-Adenosylhomocysteine and Protein Methylation. Update on the Synthesis of N-Methylamino Acids. Biological Effects of Methylated Amino Acids. Methylated Polypeptide Models. Nonenzymatic Protein Methylation and Its Biological Significance

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