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Randomised Controlled Trials

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Table of Contents

Foreword by Dr. Sholom Glouberman. Preface to the first edition. Acknowledgments. Acknowledgments from the first edition. Introduction to the second edition. Introduction to the first edition. 1. Randomized controlled trials: the basics. 2. Types of randomized controlled trials. 3. Bias in randomized controlled trials. 4. Assessing the quality of randomized controlled trials: why, what, how, and by whom?. 5. Reporting and interpreting individual trials: the essentials. 6. From individual trials to groups of trials: reviews, meta-analyses, and guidelines. 7. From trials to decisions: the basis of evidence-based health care. 8. Ethics and clinical trials: are they compatible?. 9. Reprise: more musings. Index

About the Author

The combined biography of Drs Jadad and Enkin: There is a 40-year difference in age between us and we come from vastly different backgrounds. Nevertheless, during more than a decade we have recognized the extent to which our paths and thinking have converged. We first noticed this in Oxford with our mutual interest in systematic reviews and confirmed it at McMaster University as we became painfully aware of the pitfalls of over reliance on quantitative evidence and its limited influence on health care. During the past 5 years, our focus has been more on the value of rhetoric, information and communication technologies, complex systems and the importance of effective communication in the health system. Over the years, we have grown together in our understanding, have worked together on a variety of projects, and mutually reinforced our views on clinical evidence. We are happy to share our expanding vision of randomized trials in this new edition of the book. Alejandro R Jadad MD, DPhil, FRCPC Alex Jadad s work helps improve health and wellness for all, through innovative uses of information and communication technologies. He is a physician, researcher, educator and public advocate. He obtained a doctoral degree from Oxford University for work on meta-analysis of clinical trials, and was the founding Director of the McMaster Evidence-based Practice Centre. He developed The Jadad Scale (the most widely used tool to assess clinical trial quality in the world); the Centre for Global eHealth Innovation; and a virtual platform for global collaboration, and to enable the public to shape the health system and society, worldwide. Murray W Enkin MD, FRCSC, FACOG, DSc. (hon), LLD (hon) Murray Enkin is Professor Emeritus, Departments of Clinical Epidemiology and Biostatistics, Obstetrics and Gynecology, in the Faculty of Health Sciences, McMaster University. He has been a rural family doctor, obstetrician/gynecologist, and health care researcher, and is a co-author of three books, including Effective Care in Pregnancy and Childbirth, regarded as one of the most influential books in medicine and one of the foundational pillars of evidence-based decision-making. Dr. Enkin is concerned about the risks associated with over reliance on quantitative evidence and its influence on health care, a view shared by Dr. Jadad.


"This well written book is both concise and comprehensive. This is the sort of book that students will appreciate when they first learn about clinical trials the busy health professional will use as a quick reference guide the lay person will understand and the experienced investigator will benefit from because it will challenge and defy current paradigms." (HerbalGram, February 2009) "The most useful, important, relevant, thoughtful, and thought-provoking books about medical research ... .The readers of this new book may feel a little confused or tired or worried about aspects of clinical trials, but they are sure to find a great deal of help and support at the same time. Congratulations-as always-to Alejandro Jadad and the unstoppable Murray Enkin." (Birth, September 2008)

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