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The Science and Practice of Lithium Therapy


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Table of Contents

Section I: Science of Lithium: The Ion : Lithium.- Pharmacokinetics and pharmacodynamics of lithium.- Lithium : neurotransmission and cellular mechanisms pathways underlying neuroprogression in bipolar disorder.- Lithium on gene expression modulation.- Neuroimaging and lithium.- Conclusion: overview of potential mechanisms of action of lithium in bipolar disorder.- Section II: Practice of Lithium Therapy.- Introduction of lithium in Medicine and Psychiatry.- Lithium Response variability.- Lithium Response variability: Pharmacogenomics studies.- Lithium Response variability: Biomarkers.- Lithium in acute and maintenance treatment of bipolar disorders.- Lithium and suicide prevention.- Lithium in Bipolar disorders international guidelines.- Lithium and pregnancy.- Lithium in children and adolescents.- Short and mid-term side effects of lithium.- Lithium, kidneys, renal failure.- Lithium intoxication.- Discontinuation and re-use of lithium.- Conclusion : overview of indications and monitoring of lithium in bipolar disorders.

About the Author

Gin S. Malhi, BSc Hons), MBChB, FRCPsych, FRANZCP, MD is Professor of Psychiatry and Chair in the Faculty of Medicine at the University of Sydney. He is Department Head at Royal North Shore Hospital where he is Director of the CADE Clinic, and Medical Director of the Mood Disorders Unit at Northside Clinic, Sydney. After graduating with degrees in Pharmacology and Medicine from the University of Manchester (UK), he completed his psychiatry training in Cambridge and then the Bethlem and Maudsley Hospitals in London. As a Clinical Lecturer at the Institute of Psychiatry (IOP) in London he pursued research in depression and psychosurgery, and upon moving to Sydney (Australia) in 1999 he began research in neuroimaging and bipolar disorder at the University of New South Wales (UNSW). Since 2003 he been a Chief Investigator on successive National Health Medical Research Council (NHMRC) Program Grants and during this time he has published more than 400 papers and 20 books/book chapters. After serving as Editor-in-Chief of Acta Neuropsychiatrica he has been the Editor-in-Chief of the Australian and New Zealand Journal of Psychiatry since 2010 and is now also an Editor of Bipolar Disorders. In 2013 he received the Royal Australian and New Zealand College of Psychiatrists (RANZCP) Senior Academic Researcher Prize, and then in 2015 the RANZCP College Citation, and in the same year the Mogens Schou Award from the International Society of Bipolar Disorders for Education and Teaching. In 2016, in recognition of his many achievements, he received the Distinguished Professor Award from the University of Sydney.Marc Masson, MD, is a Psychiatrist and the Medical Director of the Nightingale Hospital Paris-Clinique du Chateau de Garches and Consultant, Service Hospitalo-Universitaire, Centre Hospitalier Sainte-Anne, Paris, France. After graduating from Bordeaux University in France, he worked as a psychiatrist at Assistance Publique Hopitaux de Paris (APHP). He has served as General Secretary of The Societe Medico-Psychologique and Editor-in-chief Assistant of The Annales Medico-Psychologiques and is now the Editor-in-Chief of L'Encephale. His main areas of interest are bipolar disorders, psychopharmacology, neuropsychiatry and the history of psychiatry, and has published 4 books and 45 papers.
Frank Bellivier MD, PhD is Professor of Adult Psychiatry at University Denis Diderot in Paris, and Head of the Departments of Psychiatry and Addiction at Saint-Louis - Lariboisiere - F. Widal hospitals in Paris. He is also director of a research team on neuropsychopharmacology of bipolar disorders and addictions at the Institut National de la Sante et de la Recherche Medicale (INSERM UMRS_1144, He received his medical degree at the University of Paris (Rene Descartes). There, he also completed his residency training and a PhD in Neurosciences, before undertaking a research fellowship at Pitie-Salpetriere Hospital, Paris. He has led several large clinical programmes for patients with mood disorders, including the Early Onset Bipolar Disorders Program, funded by INSERM and the Assistance Publique Hopitaux de Paris (APHP). Since 2007, he has led collaborative research programmes on genetic vulnerability factors in bipolar disorders and is currently conducting a prospective follow-up study on cognitive deficits and relapse risk factors in bipolar disorder. He is the recipient of several research prizes including the University of Paris 12 Research Prize (2000), the Jules Baillarger Prize (2002) and the NARSAD Independent Investigator Award (2004). His ongoing research program on biomarkers of lithium response is funded by the National Research Agency (ANR generique 2014), the Sorbonne Paris Cite University, the French Ministry of Research (PHRC) and the FondaMental/Dassault Fondations Research Prize (2013). He has published over 200 papers and is the author of many books and book chapters.


"This is a clear and comprehensive guide to the clinical use of lithium based on our current understanding of its mechanisms of actions and therapeutic effectiveness. ... The intended audience is anyone working in the field of mood disorders and involved with the use of lithium therapy. The book is a valuable resource for psychiatrists, psychiatric residents, medical students, mental health professionals, patients, and their families, as well as health professionals who treat patients who are being prescribed this agent." (Michael Easton, Doody's Book Reviews, March, 2017)"This book is a comprehensive review of lithium, a simple but powerful molecule with profound benefits to patients. ... It will be of interest for clinicians and researchers worldwide as well as to patients and their families- the recipients of lithium therapy." (Branka Aukst Margetic, Alcoholism and Psychiatry Research, Vol. 53 (1), 2017)

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