Prologue: Signal transduction, origins and personalities. First messengers. Receptors. GTP-binding proteins and signal transduction. Effector enzymes coupled to GTP-binding proteins: adenylyl cyclase and phospholipase. The regulation of visual transduction. Calcium and signal transduction. Calcium signalling. Phosphorylation and dephosphorylation:protein kinases A and C. Growth Factors :setting the framework. Signalling pathways operated by receptor protein tyrosine kinases. Signalling pathways operated by non-receptor protein tyrosine kinases. Phosphoinositide 3-kinases. Signal transduction to and from adhesion molecules. Adhesion molecules and trafficking of leukocytes. Signalling through receptor bound protein serine-threonine kinases. Protein dephosphorylation and protein phosphorylation. Protein domains and signal transduction.
Key Features * Coherent, precise text providing insight in depth to a subject that is central to cell biology and fundamental to many areas of biomedicine * Extensive conceptual colour artwork assists with the comprehension of key topics * Extensive referencing provides an invaluable link to the core and historical literature * Margin notes highlighting milestones in the evolution of our understanding of signalling mechanisms
Ijsbrand Kramer is a professor at the University of Bordeaux, working in the European Institute of Chemistry and Biology (IECB). He holds a Bachelors and Masters degree in BioMedicine from the University of Utrecht, The Netherlands, with a one year research-excursion in the Department of Cell Biology at the University of Liverpool, UK. He did his Ph.D. at the University of Amsterdam, in the Central Laboratory of Blood transfusion services (Stichting Sanquin) and worked as a post-doctoral fellow at the Hubrecht Laboratory in Utrecht and at the University of Washington in Seattle. He then took a lecturer position at the Department of Pharmacology at University College London, where he taught Signal Transduction (with Bastien Gomperts and Pether Tatham) and Pharmacology. Both teaching activities have been documented in textbooks: Signal Transduction (3 editions) and Receptor Pharmacology (CRC Press/Taylor Francis Group, 3 editions). Most of his research centers on the theme of inflammation, starting with neutrophils and the NADPH oxidase, synovial fibroblasts and destruction of the joint and more recently podosomes formation and extracellular matrix destruction in vascular endothelium. He moved to the University of Bordeaux for family reasons and switched from Pharmacology to Cell Biology, with a strong contribution to an introductory course for 1st year university students. Given the important teaching load and the general low level of student engagement in higher education he started to investigate the reasons for student failure (finding out about their expectations and attitudes) and the role of images and animations in comprehension. Scientific publications, web-based multimedia resources and dramatically enhanced retention rates (from 33 to 85%) are the fruits of these activities. At the same time he organized with University College London and Universitat Pompeu Fabra, Barcelona, summer schools on Receptor and Signalling Mechanism. He has been co-director of two European Programmes (Interbio and Transbio) that aimed at enhancing industrial innovation in the biomedical sector in the South West European Region (SUDOE). For book/publicity purposes, image of the author by Maarten Kramer
"Signal Transduction is indispensable for modern life sciences." -BIOELECTROCHEMISTRY (April 2003) "...most useful to senior undergrad and grad students entering the field, but will also provide a valuable reference for established researchers." -CELL "The text is strikingly comprehensive...Written with a single voice, the chapters integrate elegantly with one another, and provide the reader with both broad and comprehensive viewpoints...Remarkably current and up-to-date, the book promises to be a core text for graduate and advanced undergraduate courses in cell signaling and molecular cell biology, and a valuable reference book for all scientists whose work involves mechanisms of cell communication." -Michael B. Yaffe, M.I.T.