Prologue: Signal transduction, origins and personalities. First messengers. Receptors. GTP-binding proteins and signal transduction. Effector enzymes coupled to GTP-binding proteins: adenylyl cyclase and phospholipase. The regulation of visual transduction. Calcium and signal transduction. Calcium signalling. Phosphorylation and dephosphorylation:protein kinases A and C. Growth Factors :setting the framework. Signalling pathways operated by receptor protein tyrosine kinases. Signalling pathways operated by non-receptor protein tyrosine kinases. Phosphoinositide 3-kinases. Signal transduction to and from adhesion molecules. Adhesion molecules and trafficking of leukocytes. Signalling through receptor bound protein serine-threonine kinases. Protein dephosphorylation and protein phosphorylation. Protein domains and signal transduction.
* Coherent, precise text providing insight in depth to a subject that is central to cell biology and fundamental to many areas of biomedicine * Conceptual colour artwork assists with the comprehension of key topics * Extensive referencing provides an invaluable link to the core and historical literature * Margin notes highlighting milestones in the evolution of our understanding of signalling mechanisms
Bastien D. Gomperts
"Signal Transduction is indispensable for modern life sciences." -BIOELECTROCHEMISTRY (April 2003) "...most useful to senior undergrad and grad students entering the field, but will also provide a valuable reference for established researchers." -CELL "The text is strikingly comprehensive...Written with a single voice, the chapters integrate elegantly with one another, and provide the reader with both broad and comprehensive viewpoints...Remarkably current and up-to-date, the book promises to be a core text for graduate and advanced undergraduate courses in cell signaling and molecular cell biology, and a valuable reference book for all scientists whose work involves mechanisms of cell communication." -Michael B. Yaffe, M.I.T.