Table of Contents

List of Contributors, vii

1 Hepatocytes 1
Jean-François Dufour and Joachim C. Mertens

2 Signaling pathways in biliary epithelial cells 15
M. Fatima Leite, Mateus T. Guerra, Viviane A. Andrade and Michael H. Nathanson

3 Stellate cells 34
Alessandra Caligiuri and Fabio Marra

4 Kupffer cells 61
Amirali Kiyani and Ekihiro Seki

5 Hepatic sinusoidal endothelial cells 73
Moira B. Hilscher Robert C. Huebert and Vijay H. Shah

6 Extracellular matrix 85
Scott L. Friedman

7 Platelets: a new cell type in liver physiology 97
Mickaël Lesurtel and Pierre]Alain Clavien

8 Immune cell communication in liver disease and liver regeneration 110
R. Harminder Boghal, B.F. Stephenson and Simon C. Afford

9 Extracellular vesicle RNA in liver disease 130
Tushar Patel and Hiroaki Haga

10 Endoplasmic reticulum stress in nonalcoholic fatty liver disease 139
Fabienne Foufelle and Pascal Ferré

11 Autophagy 151
Hao Zhang, Bilon Khambu and Xiao]Ming Yin

12 CXC chemokine receptor signaling in liver repair and regeneration 166
Gregory C. Wilson, Christopher M. Freeman, Hiroyuki Nojima and Alex B. Lentsch

13 Metabolic regulation of liver regeneration 174
Jiansheng Huang and David A. Rudnick

14 TNF signaling 186
Amrit Mann, Mark J. Czaja and Jörn M. Schattenberg

15 Fas/FasL 203
Maria Eugenia Guicciardi and Gregory J. Gores

16 Interferon signaling 214
Markus H. Heim

17 Endocannabinoid signaling in liver pathologies 226
Bostjan Humar and Nasser Semmo

18 The WNT/β]catenin pathway 240
Satdarshan P. Singh Monga

19 Hedgehog signaling in the liver 262
Mariana V. Machado and Anna Mae Diehl

20 Notch pathway 275
Sonja Rothweiler and David Semela

21 PI3K/PTEN signaling in liver diseases 287
Alfredo Fort, Nicolas Calo, Dorothea Portius, Lucie Bourgoin, Marion Peyrou and Michelangelo Foti

22 mTOR signaling in liver disease 314
Marion Cornu, Grégoire de Caudron de Coquereaumont and Michael N. Hall

23 LKB1/AMPK pathway in the control of hepatic energy metabolism 326
Benoit Viollet and Marc Fortes

24 NF-κB 339
Ekihiro Seki and David A. Brenner

25 c-Jun NH2]terminal kinases in liver diseases 348
Johannes Kluwe and Robert F. Schwabe

26 p53 364
Aundrietta D. Duncan, Wen]Wei Tsai and Michelle Craig Barton

27 Sirtuins 374
Frank K. Huynh, Eoin McDonnell, Kristin A. Anderson and Matthew D. Hirschey

28 Bile acids and their receptors 385
Thierry Claudel and Michael Trauner

29 Hepcidin and iron 400
Chiara Vecchi and Antonello Pietrangelo

30 Gut microbiome and liver diseases 411
Herbert Tilg and Alexander R. Moschen

31 Epigenetic regulation of hepatic stellate cells and liver fibrosis 421
Jelena Mann and Derek A. Mann

32 Signaling in hepatocellular carcinoma 435
Adam Pennycuick and Augusto Villanueva

33 Interplay between hepatitis B virus and innate immune signaling pathways 448
Barbara Testoni, David Durantel and Fabien Zoulim

34 Signaling of hepatitis C virus 459
Joachim Lupberger, Nicolaas Van Renne and Thomas F. Baumert

35 Oxidative stress and signaling in the liver 469
Mitchell R. McGill, Yuchao Xie and Hartmut Jaeschke

Index 000

About the Author

Professor Jean-François Dufour, MD, PhD, Chief, Department of Clinical Pharmacology, University Clinic Visceral Surgery and Medicine, Bern, Switzerland.
Professor Dufour is on the governing board of the European Association for the Study of the Liver (EASL).  He also serves as Associate Editor for the Wiley journal Liver International and is on the editorial board for the following journals: Journal of Hepatology; Clinical Science; World Journal of Gastroenterology

Professor Pierre-Alain Clavien, MD, PhD, FACS, FRCS (Eng), FRCS (Ed), Professor and Chairman, Department of Surgery. Head, Division of Visceral & Transplantation Surgery, University Hospital Zurich, Switzerland.
Professor Clavien is a world-wide renowned surgeon-scientist, currently professor and chairman of the Department of Surgery in Zurich, Switzerland.  His areas of research include organ preservation, liver ischemia-reperfusion injury and regeneration, and pathogenesis of cancer, as well as outcome research. He received many competitive grants and awards, including one of the most prestigious prices for scientific research, the Otto Naegeli Award.