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Here, There be dragons....- The Basis of Statistical Reasoning in Medicine.- Probability Tools for Monitoring Rules.- Issues and Intuition in Path Analysis.- Group Sequential Analysis Procedures.- Looking Forward: Conditional Power.- Safety and Futility.- Bayesian Statistical Monitoring.
From the reviews: "This book is aimed at helping clinical researchers, who have little or no quantitative background and who have difficulty in communicating with biostatisticians or experienced trial methodologists. ... The author has a wealth of experience in this area and this is demonstrated throughout the text with relevant poignant examples. Each chapter has a comprehensive reference list and a set of problems ... . A book to recommend for students/researchers who need to be able to apply correct use and monitor procedures for clinical investigations." (S. Starkings, Short Book Reviews, Vol. 26 (1), 2006) "The present book is designed to provide a useful presentation of eight detailed, well written parts of statistical techniques in clinical research, a useful tool in statistical monitoring of clinical trials. In particular, the aim of the present book is to give a consistent and self-contained overview on important fundamental and modern procedures used by clinical investigators ... . The book is of great interest to research workers ... in the design, execution and analysis of clinical research." (Cryssoula Ganatsiou, Zentralblatt MATH, Vol. 1094 (20), 2006) "This book is written such that it can be understood without a sophisticated mathematical background....[It] is highly recommended for clinical researchers who start to serve on a DMC, but also for healthcare graduate students and junior physician-scientists....[and] is also enjoyable reading for statisticians." (Iris Pigeot, Biometrics, December 2007) "This book seems to be a successful attempt to introduce group sequential monitoring of clinical trials to a larger audience than well-trained statisticians working in the conduct of such trials. It is an important book that came on time and very much recommended for nonstatistician clinical investigators and members of the Data Monitoring Committees (DMCs) as well as statisticians who are not familiar with group sequential methodologies in clinical trials. The book is self-containing and avoids mathematical complications as much as possible." (Abdulkadir Hussein, Technometrics, Vol. 50 (1), 2008) "This book has been written to inform and help investigators understand the complex mathematical procedures and monitoring guidelines in clinical trials. ... useful for researchers and investigators who would like to understand the application of statistical principles in clinical trials. I have greatly benefited by reading this book ... providing a concise overview of such a diverse and complex field in a relatively simple and easy to understand format. This is a well-written book ... . I strongly recommend it for all academic libraries." (Faisel Yunus, Journal of Applied Statistics, Vol. 23 (10), 2007)