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Offered in print, online, and downloadable formats, this updated edition of Stroke: Pathophysiology, Diagnosis, and Management delivers convenient access to the latest research findings and management approaches for cerebrovascular disease. Picking up from where J. P. Mohr and colleagues left off, a new team of editors - Drs. Grotta, Albers, Broderick, Kasner, Lo, Mendelow, Sacco, and Wong - head the sixth edition of this classic text, which is authored by the world's foremost stroke experts. Comprehensive, expert clinical guidance enables you to recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan. Abundant full-color CT images and pathology slides help you make efficient and accurate diagnoses. Data from late-breaking endovascular trials equips you with recent findings. Includes comprehensive coverage of advances in molecular biology of cell death; risk factors and prevention; advances in diagnostics and stroke imaging; and therapeutic options, including a thorough review of thrombolytic agents and emerging data for endovascular therapy. Features brand-new chapters on Intracellular Signaling: Mediators and Protective Responses; The Neurovascular Unit and Responses to Ischemia; Mechanisms of Cerebral Hemorrhage; Stroke Related to Surgery and Other Procedures; Cryptogenic Stroke; and Interventions to Improve Recovery after Stroke. Highlights new information on genetic risk factors; primary prevention of stroke; infectious diseases and stroke; recovery interventions such as robotics, brain stimulation, and telerehabilitation; and trial design. Details advances in diagnostic tests, such as ultrasound, computed tomography (including CT angiography and CT perfusion), MRI (including MR perfusion techniques), and angiography. Includes extracted and highlighted evidence levels. Expert Consult eBook version included with print purchase. This enhanced eBook experience allows you to search all of the text, figures, and references on a variety of devices. The content can also be downloaded to tablets and smart phones for offline use. Combat stroke with the most comprehensive and updated multimedia resource on the pathophysiology, diagnosis, and management of stroke from leaders in the field
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Table of Contents

SECTION I: Pathophysiology 1 Vascular Biology and Atherosclerosis of Cerebral Vessels 2 Mechanisms of Thrombosis and Thrombolysis 3 Cerebral Blood Flow and Metabolism: Regulation and Pathophysiology in Cerebrovascular Disease 4 Histopathology of Brain Tissue Response to Stroke and Injury 5 Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death 6 Intracellular Signaling: Mediators and Protective Responses 7 The Neurovascular Unit and Responses to Ischemia 8 Mechanisms of Cerebral Hemorrhage 9 White Matter Pathophysiology 10 Inflammation and Immune Response 11 Mechanisms of Plasticity, Remodeling and Recovery 12 Genetics and Vascular Biology of Angiogenesis and Vascular Malformations SECTION II: Epidemiology and Risk Factors 13 Global Burden of Stroke 14 Stroke Disparities 15 Modifiable Risk Factors and Determinants of Stroke 16 Prognosis after Stroke 17 Vascular Dementia and Cognitive Impairment 18 Genetic Basis of Stroke Occurrence, Prevention and Outcome 19 Preventing a First Stroke SECTION III: Clinical Manifestations 20 Classification of Ischemic Stroke 21 Clinical Scales to Assess Patients with Stroke 22 Carotid Artery Disease 23 Anterior Cerebral Artery Disease 24 Middle Cerebral Artery Disease 25 Posterior Cerebral Artery Disease 26 Vertebrobasilar Disease 27 Lacunar Syndromes, Lacunar Infarcts, and Cerebral Small Vessel Disease 28 Intracerebral Hemorrhage 29 Aneurysmal Subarachnoid Hemorrhage 30 Arteriovenous Malformations and Other Vascular Anomalies 31 Stroke and Other Vascular Syndromes of the spinal Cord SECTION IV: Specific Conditions and Stroke 32 Cardiac Diseases 33 Atherosclerotic Disease of the Proximal Aorta 34 Stroke Related to Surgery and Other Procedures 35 Arterial Dissections and Fibromuscular Dysplasia 36 Collagen Vascular and Infectious Diseases 37 Reversible Cerebral Vasoconstriction Syndromes 38 Hypertensive Encephalopathy 39 Stroke and Substance Abuse 40 Moyamoya Disease 41 CADASIL: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy 42 Hematologic Disorders and Stroke 43 Migraine and Stroke 44 Cryptogenic Stroke 45 Cerebral Venous Thrombosis SECTION V: Diagnostic Studies 46 Ultrasonography 47 Computed Tomography-based Evaluation of Cerebrovascular Disease 48 Magnetic Resonance Imaging of Cerebrovascular Diseases 49 Cerebral Angiography SECTION VI: Therapy Part A: Medical Therapy 50 Prehospital and Emergency Department Care of the Patient with Acute Stroke 51 Intravenous Thrombolysis 52 Antithrombotic Therapy for Treatment of Acute Ischemic Stroke 53 General Stroke Management and Stroke Units 54 Critical Care of the Patient with Acute Stroke 55 Pharmacologic Modification of Acute Cerebral Ischemia 56 Treatment of "Other" Stroke Etiologies 57 Medical Therapy of Intracerebral and Intraventricular Hemorrhage 58 Rehabilitation and Recovery of the Patient with Stroke 59 Interventions to Improve Recovery after Stroke 60 Enhancing Stroke Recovery with Cellular Therapies 61 Antiplatelet Therapy for Secondary Prevention of Stroke 62 Secondary Prevention of Cardioembolic Stroke 63 Conduct of Stroke-Related Clinical Trials Part B: Interventional Therapy 64 Endovascular Therapy of Extracranial and Intracranial Occlusive Disease 65 Endovascular Treatment of Acute Ischemic Stroke 66 Endovascular Treatment of Cerebral Aneurysms 67 Interventional Therapy of Brain and Spinal Arteriovenous Malformations 68 Dural Arteriovenous Malformations Part C: Surgical Therapy 69 Surgery of Anterior and Posterior Aneurysms 70 Surgery for Intracerebral Hemorrhage 71 Intraventricular Hemorrhage 72 Surgical Management of Cranial and Spinal Arteriovenous Malformations 73 Surgical Cavernous Malformations and Venous Anomalies 74 Indications for Carotid Endarterectomy in Patients with Asymptomatic and Symptomatic Carotid Stenosis 75 Extracranial to Intracranial Bypass for Cerebral Ischemia 76 Decompressive Craniectomy for Infarction and Hemorrhage

About the Author

Professor of Neurology, Chairman, Department of Neurology, University of Texas Medical School at Houston; Director, Stroke Program, Memorial Hermann - Texas Medical Center, Houston, TX Eng H. Lo. Ph.D. (Editor) Massachusetts General Hospital, Harvard Medical School, Boston, MA Dr. Lo is currently Head of the Neuroprotection Research Laboratories at Massachusetts General Hospital and Professor of Neuroscience in Harvard Medical School. For over 25 years, Dr. Lo has contributed to research delineating mechanisms of injury and repair in the central nervous system.


"Authoritative, eminently readable, and current."-Journal of Neurosurgery "[F]or depth of coverage of individual subjects and as a reference for cerebrovascular diseases, [Stroke] has become the standard."-Annals of Internal Medicine "Should be part of the libraries of all [those] who deal with cerebrovascular disease." -JAMA "Updating such a big reference work is a huge task, and by and large the editors have succeeded in their task. They have assembled many very distinguished authors and put together a pretty comprehensive reference work." -Journal of Neurology Neurosurgery and Psychiatry Reviews of previous edition. "There are sections on pathophysiology, epidemiology, clinical manifestation and individual sections dealing with specific pathological conditions explaining each in great depth. In addition, it has extensive sections devoted to therapy including medical, interventional and surgical. All this makes the book a one-stop-shop for stroke. As a result, it is a work that will prove valuable to a wide range of clinicians involved with providing stroke services, including stroke physicians, acute care physicians, researchers, public health physicians and those involved with rehabilitation medicine...In comparison to the previous editions, the book has definite a advantages in the form of picture quality and web access. It is excellent value for the price as a reference book for stroke, not radiology specific. The book would find its place in a departmental radiology library. Overall, an excellent, up-to-date reference volume." RAD, May 2012

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