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List of Contributors, ix Preface, xvii List of Abbreviations, xix Section 1 Genitourinary Cancer 1 Uncommon Tumors of the Kidney, 1 Khaled Ali, Ming Zhou, Steve Campbell, Ronald M. Bukowski, and Brian I. Rini 2 Uncommon Cancers of the Bladder, 23 Arlene O. Siefker-Radtke, Bogdan A. Czerniak, Colin P. Dinney, and Randall E. Millikan 3 Urethral Cancer, 35 Sonia L. Ali, Tanya B. Dorf, Paul G. Pagnini, and David I. Quinn 4 Uncommon Cancers of the Prostate, 47 Scott T. Tagawa, Naveed H. Akhtar, Brian D. Robinson, and Himisha Beltran 5 Rare Tumors of the Testis and Paratesticular Tissues, 77 Robert Huddart, Stephen Hazell, and Alan Horwich Section 2 Head and Neck Cancer 6 Uncommon Tumors of the Oral Cavity and Adjacent Structures, 97 Voichita Bar-Ad, Madalina Tuluc, David Cognetti, and Rita Axelrod 7 Rare Tumors of the Larynx, 119 Kyle Mannion, Kenneth J. Niermann, Joseph M. Aulino, and Barbara A. Murphy 8 Nasopharyngeal Carcinoma in Nonendemic Populations, 131 June Corry and Bonnie S. Glisson 9 Esthesioneuroblastoma, 151 Barbara A. Murphy, Salyka Sengsayadeth, Joseph M. Aulino, Christine H. Chung, Kim Ely, Robert J. Sinard, and Anthony J. Cmelak Section 3 Endocrine Tumors 10 Adrenal Neoplasms, 163 Alexandria T. Phan, Mouhammed A. Habbra, Elizabeth G. Grubbs, and Cesar Moran 11 Uncommon Cancers of the Thyroid, 189 Sonia Abuzakhm, Mark Bloomston, and Manisha H. Shah 12 Parathyroid Carcinoma, 201 Rodrigo Arrangoiz and John A. Ridge Section 4 Breast Cancer 13 Metaplastic Breast Carcinoma, 211 Ingrid A. Mayer, Helenice Gobbi, and A. Bapsi Chakravarthy 14 Adenoid Cystic Carcinoma of the Breast, 217 Melinda E. Sanders, Masako Kasami, Julie Means-Powell, and David L. Page 15 Non-Hodgkin Lymphoma of the Breast, 225 David S. Morgan and Jean F. Simpson 16 Male Breast Cancer, 233 Nicole M. Randall, Kathy D. Miller, and George W. Sledge Jr. 17 Phyllodes Tumor of the Breast, 243 Emad A. Rakha and Ian O. Ellis 18 Carcinosarcoma of the Breast, 257 Stacy L. Moulder, Bryan T. Hennessy, Michael Z. Gilcrease, Gildy Babiera, Wei Yang, Vicente Valero, and Gabriel N. Hortobagyi 19 Tubular Carcinoma, 271 Melinda E. Sanders, Ingrid A. Mayer, and A. Bapsi Chakravarthy Section 5 Thoracic Tumors 20 Thymoma and Thymic Carcinoma, 279 Patrick J. Loehrer Sr., Mark R. Wick, and Sunil Badve 21 Primary Sarcomas of the Lung, 303 Regan M. Duffy, Amanda VanSandt, and Alan B. Sandler 22 Mesotheliomas, 319 Giuseppe Giaccone, Anish Thomas, and Arun Rajan 23 Primary Melanoma of the Lung, 335 Richard A. Scolyer, James F. Bishop, and John F. Thompson 24 Large Cell Neuroendocrine Carcinoma, 343 William D. Travis, M. Catherine Pietanza, and Inderpal (Netu) S. Sarkaria 25 Bronchioloalveolar Carcinoma of the Lung, 355 Gregory J. Riely and Vincent A. Miller 26 Primary Adenoid Cystic Carcinoma of the Lung, 365 John G. Devlin and Corey J. Langer Section 6 Gastrointestinal Tumors 27 Uncommon Tumors of the Esophagus, 373 Lawrence Leichman and Robert Rosser 28 Uncommon Cancers of the Stomach, 389 Elizabeta Popa, Felice Schnoll-Sussman, Arun Jesudian, Govind Nandakumar, and Manish A. Shah 29 Unusual Cancers of the Pancreas, 409 Chanjuan Shi, John S. Macdonald, and Jordan D. Berlin 30 Uncommon Hepatobiliary Tumors, 423 Abby B. Siegel, Vladimir Sheynzon, and Benjamin Samstein 31 Cancers of the Small Bowel, 441 Kanwal Raghav, Matthew H. G. Katz, and Michael J. Overman 32 Unusual Tumors of the Colon, Rectum, and Anus, 453 Diane Reidy-Lagunes, Karyn Goodman, and Leonard B. Saltz 33 Gastrointestinal Stromal Tumors, 465 Margaret von Mehren, Douglas B. Flieder, and Chandrajit P. Raut Section 7 Gynecological Cancers 34 Extraovarian Primary Peritoneal Carcinomas, 485 Alberto E. Selman and Larry J. Copeland 35 Borderline Tumors and Other Rare Epithelial Tumors of the Ovary, 497 Ramez N. Eskander, Teresa P. Diaz-Montes, Russell Vang, Deborah K. Armstrong, and Robert E. Bristow 36 Stromal Tumors of the Ovary, 507 Jubilee Brown, Anuja Jhingran, and Michael Deavers 37 Germ Cell Tumors of the Ovary, 519 Daniela E. Matei, Jeanne M. Schilder, and Helen Michael 38 Fallopian Tube Cancer, 531 Destin Black and Richard R. Barakat 39 Nonendometrioid Endometrial Carcinomas and Uterine Sarcomas, 541 Peter G. Rose and Charles Biscotti 40 Tumors of the Cervix, 567 Krishnansu S. Tewari and Bradley J. Monk 41 Tumors of the Vulva and Vagina, 587 Joshua P. Kesterson and Shashikant B. Lele Section 8 Hematological Malignancies 42 Rare Acute Leukemias, 601 B. Douglas Smith and Eunpi Cho 43 Unusual Myelodysplastic Syndromes and Myeloproliferative Neoplasms, 611 Eric Padron and Rami Komrokji 44 Rare B Cell Lymphoproliferative Disorders, 617 Paul M. Barr and Jonathan W. Friedberg 45 Uncommon Presentations of Plasma Cell Dyscrasias, 627 Rachid Baz and Mohamad A. Hussein 46 Rare Bone Marrow Failure Conditions, 637 Valeria Visconte and Ramon V. Tiu 47 Myeloproliferative Neoplasms: Chronic Myelogenous Leukemia, Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis, 647 Raoul Tibes, Gurcharan Singh Khera, and Ruben A. Mesa 48 Rare T Cell Lymphomas, 659 Aleksandr Lazaryan and John Sweetenham Section 9 Cutaneous Malignancies 49 Unusual Cutaneous Malignancies, 667 Sara Peters and Thomas Olencki 50 Dermatofibrosarcoma Protuberans, 685 Michael Alvarado, Jane L. Messina, Rahel Mathew, and Vernon K. Sondak 51 Unusual Melanomas, 691 Omid Hamid, Richard D. Carvajal, Donald L. Morton, and Mark Faries Section 10 Neurological Malignancies 52 Primary Melanotic Tumors of the Central Nervous System, 709 L. Burt Nabors, Rong Li, Cheryl A. Palmer, and Philip R. Chapman 53 Langerhans Cell Histiocytosis of the Central Nervous System, 715 Rima F. Jubran and Jonathan L. Finlay 54 Chordomas, 721 Herbert B. Newton 55 Atypical and Malignant Meningiomas, 733 George A. Alexiou, Samer E. Kaba, and Athanassios P. Kyritsis 56 Primary Central Nervous System Lymphoma, 747 Lisa M. DeAngelis 57 Choroid Plexus Papilloma and Carcinoma, 759 Derek R. Johnson and Julie E. Hammack 58 Glioma and Other Neuroepithelial Neoplasms, 767 Kevin T. Palka, Brett Mobley, Stephanie Perkins, Michael Cooper, Allen K. Sills, and Paul L. Moots 59 Medulloblastoma in Adults, 795 Paul L. Moots and Anna Marie Kenney 60 Pineal Parenchymal Tumors, 813 Shota Tanaka, Stephen W. Clark, and Patrick Y. Wen 61 Craniopharyngiomas, 823 Gazanfar Rahmathulla, John J. Park, and Gene H. Barnett 62 Ophthalmic Cancers, 835 Maria M. Choudhary and Arun D. Singh Section 11 Pediatric Malignancies 63 Introduction to Rare Cancers of Childhood, 847 Alberto S. Pappo and Gregory H. Reaman 64 Uncommon Tumors of the Gastrointestinal Tract in Children, 851 Alberto S. Pappo and Wayne L. Furman 65 Rare Pediatric Malignancies of the Head and Neck, 867 Cynthia E. Herzog, Michael E. Kupferman, Winston Huh, and Anita Mahajan 66 Uncommon Pediatric Tumors of the Thorax, 877 Yoav H. Messinger, Kris Ann P. Schultz, and Louis P. Dehner 67 Uncommon Adrenal Tumors in Children and Adolescents, 903 Raul C. Ribeiro, Carlos Rodriguez-Galindo, Emilia M. Pinto, Gerard P. Zambetti, and Bonald C. Figueiredo 68 Uncommon Pediatric Genitourinary Tumors, 915 Barbara Bambach, Hans G. Pohl, and Jeffrey S. Dome 69 Uncommon Pediatric Brain Tumors, 927 Robert C. Castellino, Matthew Schniederjan, and Tobey J. MacDonald 70 Malignant Tumors of the Skin and Subcutaneous Tissue in Children, 943 Alberto S. Pappo and Carlos Rodriguez-Galindo Index, 959
Derek Raghavan, MD, PhD, is President of the Levine CancerInstitute of the Carolinas Healthcare System in Charlotte,North Carolina. Widely published in journals and books, Dr.Raghavan has been the editor-in-chief of Textbook of UncommonCancer since its second edition. Charles D. Blanke, MD, is Chief of the Division ofOncology at the British Columbia Cancer Agency and Professor ofMedicine at the University of British Columbia in Vancouver,Canada. David Johnson, MD, was the longtime Director of theDivision of Hematology and Oncology at Vanderbilt University inNashville, Tennessee, and was recently appointed as Chairman ofMedicine and holds the Donald W. Seldin Distinguished Chair inInternal Medicine at the University of Texas Southwestern inDallas, Texas. Paul L. Moots, M.D., Associate Professor of Neurology atthe Vanderbilt-Ingram Cancer Center in Nashville, Tennessee. Gregory H. Reaman, M.D., is Chair of the Children'sOncology Group at the Children s National Medical Center inWashington, DC. Peter G. Rose, MD, is Section Head and FellowshipDirector of Gynecologic Oncology in the Department ofObstetrics and Gynecology at the Cleveland Clinic. Mikkael A. Sekeres, MD, is Director of the LeukemiaProgram at the Cleveland Clinic Taussig Cancer Institute.