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Vascular Cognitive Impairment in Clinical Practice


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Table of Contents

List of contributors; Preface; Part I. Diagnosis: 1. Diagnosing vascular cognitive impairment and dementia - concepts and controversies Timo Erkinjuntti and Serge Gauthier; 2. Vascular cognitive impairment - prodrome to VaD? Adriane Mayda and Charles DeCarli; 3. Clinical evaluation: a systematic but user-friendly approach Oscar L. Lopez and David A. Wolk; 4. Cognitive functioning in vascular dementia before and after diagnosis Erika J. Laukka, Sari Karlsson, Stuart W. S. MacDonald and Lars Backman; 5. Structural neuroimaging: CT and MRI Wiesje M. van der Flier, Salka S. Staekenborg, Frederik Barkhof and Philip Scheltens; 6. Functional imaging in vascular dementia - clinical practice Lars-Olof Wahlund and Rimma Axelsson; 7. Biomarkers in vascular dementia Anders Wallin and Tuula Pirttila; Part II. Pathophysiology: 8. Physio-pathology of large vessel vascular dementia Leonardo Pantoni, Francesca Pescini and Anna Poggesi; 9. Small vessel diseases of the brain Raj N. Kalaria and Timo Erkinjuntti; 10. White matter changes Franz Fazekas, Christian Enzinger, Stefan Ropele and Reinhold Schmidt; 11. Hereditary forms of cerebrovascular amyloidosis Agueda Rostagno and Jorge Ghiso; 12. Role of vascular risk factors in dementia Chengxuan Qiu and Laura Fratiglioni; 13. Cardiovascular disease, cognitive decline, and dementia Angela L. Jefferson and Emelia J. Benjamin; 14. Vascular factors in Alzheimer's disease: from diagnostic dichotomy to integrative etiology Miia Kivipelto, Alina Solomon and Tiia Ngandu; Part III. Treatment: 15. Treatment of cognitive changes Serge Gauthier and Timo Erkinjuntti; 16. Treatment of functional decline Lena Borell; 17. Treatment of behavioral symptoms in vascular dementia Catherine Cole and Alistair Burns; 18. Control of vascular risk factors Deborah Gustafson and Ingmar Skoog; Index.

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Gives a broad clinical perspective on vascular cognitive impairment, and creates a foundation for the implementation of good dementia care.

About the Author

Lars-Olof Wahund is a Professor at the Department of Neurobiology, Caring Sciences and Society at the Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden. Timo Erkinjuntti is Professor of Neurology at the Department of Neurology, University of Helsinki, Helsinki, Finland. Serge Gauthier is a Professor and Director at the Alzheimer's Disease and Related Disorders Research Unit, McGill Centre for Studies on Aging, Douglas Mental Health University Institute, Montreal, Quebec, Canada.


'... this book may be recommended not just for the VaD/VCI cognoscenti, but for all those concerned with the diagnosis and management of dementia syndromes.' Advances in Clinical Neuroscience and Rehabilitation
'This is a major contribution to the field. It sorts out in clear fashion a very tangled literature. ... The excellent organisation and editing of this book, its careful elaboration of complex concepts, and the practical application of this synthesis give rise to a first-rate work. This much-needed book deserves a wide readership.' David O. Staats MD, University of Oklahoma Health Sciences Center
"This multiauthored monograph chronicles how changes in brain blood vessels affect cognition and cause dementia and other related syndromes. It is a brilliant synthesis of a complicated topic, drawing together knowledge and recent discoveries from a wide variety of disciplines....This is a major contribution to the field. It sorts out in clear fashion a very tangled literature. In the process, it points out just where future research is needed. Methodological issues of such research and the profound implications of epidemiological studies (vascular disease starts early and causes cognitive changes in midlife) are emphasized. In addition, the book provides clear outlines of the approach to differential diagnosis and management of these patients, including caregiver support. Finally, the links of heart disease to both vascular cognitive impairment and Alzheimer's disease are discussed. The excellent organization and editing of this book, its careful elaboration of complex concepts, and the practical application of this synthesis give rise to a first-rate work. This much-needed book deserves a wide readership." --Doody's Review Service

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