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Veterinary Pharmacology and Therapeutics


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Table of Contents

Contributors xiii Preface xix About the Companion Website xxi Section 1 Principles of Pharmacology 1 1 Veterinary Pharmacology: An Introduction to the Discipline 3 Jim E. Riviere and Mark G. Papich 2 Absorption, Distribution, Metabolism, and Elimination 8 Jim E. Riviere 3 Pharmacokinetics 41 Jim E. Riviere 4 Mechanism of Drug Action and Pharmacokinetics/ Pharmacodynamics Integration in Dosage Regimen Optimization for Veterinary Medicine 65 Pierre-Louis Toutain 5 Principles of Pharmaceutics and Veterinary Dosage Forms 87 Raafat M. Fahmy and Marilyn N. Martinez Section 2 Drugs Acting on the Autonomic Nervous System 111 6 Introduction to the Autonomic Nervous System and Autonomic Pharmacology 113 Joshua A. Rowe, Rose M. McMurphy, Barbara J. Lutjemeier, and Michael J. Kenney 7 Adrenergic Receptor Agonists and Antagonists 131 Rose M. McMurphy, Elizabeth G. Davis, Amy J. Rankin, Daniel A. Frese, Barbara J. Lutjemeier, and ;Michael J. Kenney 8 Cholinergic Pharmacology: Autonomic Drugs 151 Rose M. McMurphy, Elizabeth G. Davis, Amy J. Rankin, Marjory A. Artzer, Barbara J. Lutjemeier, and Michael J. Kenney Section 3 Anesthetics and Analgesics, and Drugs Acting on the Central Nervous System 165 9 Introduction to Drugs Acting on the Central Nervous System and Principles of Anesthesiology 167 Peter J. Pascoe and Eugene P. Steffey 10 Neuromuscular Blocking Agents 194 Diane E .Mason and Christopher L. Norkus 11 Inhalation Anesthetics 216 Robert J. Brosnan and Eugene P. Steffey 12 Injectable Anesthetic Agents 247 Lysa P. Posner 13 Opioid Analgesic Drugs 281 Butch KuKanich and Mark G. Papich 14 Sedatives and Tranquilizers 324 Lysa P. Posner 15 Local Anesthetics 369 Thomas W. Vickroy 16 Euthanizing Agents 387 Anna Hampton 17 Anticonvulsant Drugs 395 Mark G. Papich 18 Drugs Affecting Animal Behavior 416 Margaret E. Gruen, Barbara L. Sherman, and Mark G. Papich Section 4 Autacoids and Antiinflammatory Drugs 449 19 Histamine, Serotonin, and their Antagonists 451 Wolfgang Baumer 20 Analgesic, Antiinflammatory, Antipyretic Drugs 467 Peter Lees Section 5 Drugs Acting on the Cardiovascular System 501 21 Digitalis, Positive Inotropes, and Vasodilators 503 Clarke E. Atkins and Marisa K. Ames 22 Antiarrhythmic Agents 537 Kathryn M. Meurs and Jim E. Riviere Section 6 Drugs Affecting Renal Function and Fluid-Electrolyte Balance 553 23 Principles of Acid-Base Balance: Fluid and Electrolyte Therapy, Blood Substitutes 555 Maya M. Scott-Garrard, Melisa Rosenthal, and Deborah T. Kochevar 24 Diuretics and Renal Pharmacology 593 Butch Kukanich and Deborah T. Kochevar Section 7 Drugs Acting on Blood and Blood Elements 623 25 Anticoagulant, Antiplatelet, and Hemostatic Drugs 625 Mark G. Papich Section 8 Endocrine Pharmacology 647 26 Hypothalamic and Pituitary Hormones 649 Srujana Rayalam, Margarethe Hoenig, and Duncan C. Ferguson 27 Hormones Affecting Reproduction 674 Wolfgang Baumer, C. Scott Bailey, and John Gadsby 28 Thyroid Hormone and Antithyroid Drugs 691 Duncan C. Ferguson 29 Glucocorticoids, Mineralocorticoids, and Adrenolytic Drugs 729 Duncan C. Ferguson and Margarethe Hoenig 30 Drugs Influencing Glucose Metabolism 763 Margarethe Hoenig Section 9 Chemotherapy of Microbial Diseases 779 31 Antiseptics and Disinfectants 781 Megan E. Jacob 32 Sulfonamides and Potentiated Sulfonamides 796 Mark G. Papich 33 ?-Lactam Antibiotics: Penicillins, Cephalosporins, and Related Drugs 826 Mark G. Papich 34 Tetracycline Antibiotics 858 Mark G. Papich and Jim E. Riviere 35 Aminoglycoside Antibiotics 877 Mark G. Papich and Jim E. Riviere 36 Chloramphenicol and Derivatives, Macrolides, Lincosamides, and Miscellaneous Antimicrobials 903 Mark G. Papich 37 Fluoroquinolone Antimicrobial Drugs 953 Mark G. Papich 38 Antifungal and Antiviral Drugs 988 Jennifer L. Davis and Lara Maxwell Section 10 Chemotherapy of Parasitic Diseases 1033 39 Antinematodal Drugs 1035 Carlos E. Lanusse, Juan M. Sallovitz, Sergio F. Sanchez Bruni, and Luis I. Alvarez 40 Anticestodal and Antitrematodal Drugs 1081 Carlos E. Lanusse, Luis I. Alvarez, and Guillermo L. Virkel 41 Macrocyclic Lactones: Endectocide Compounds 1102 Carlos E. Lanusse, Fernanda A. Imperiale, and Adrian L. Lifschitz 42 Antiprotozoan Drugs 1128 Jennifer L. Davis and Jody L. Gookin 43 Ectoparasiticides 1166 Ronald E. Baynes Section 11 Specialty Areas of Pharmacology 1189 44 Chemotherapy of Neoplastic Diseases 1191 Luke A.Wittenburg and Daniel L. Gustafson 45 Immunosuppressive Drugs 1226 Mark G. Papich 46 Drugs for Treating Gastrointestinal Diseases 1245 Mark G. Papich 47 Dermatopharmacology: Drugs Acting Locally on the Skin 1278 Jim E. Riviere and Rosanna Marsella 48 Drugs that Affect the Respiratory System 1302 Mark G. Papich 49 Ophthalmic Pharmacology 1321 Alison Clode 50 Pharmacogenomics 1332 Katrina L. Mealey 51 Considerations for Treating Minor Food-Producing Animals with Veterinary Pharmaceuticals 1345 Lisa A. Tell, Margaret Oeller, Tara Marmulak, and Ronette Gehring 52 Unique Considerations Pertaining to the Use of Drugs in Food Animals 1358 Michael D. Apley 53 Pharmacology in Aquatic Animals 1373 Ron A. Miller 54 Zoological Pharmacology 1395 Robert P. Hunter Section 12 Regulatory and Other Considerations 1405 55 The Regulation of Animal Drugs 1407 Steven D. Vaughn and Marilyn N. Martinez 56 Veterinary Pharmacy 1427 Gigi Davidson and Mark G. Papich 57 Medication Control Programs in Performance Animals 1439 Cynthia A. Cole 58 Pharmacovigilance 1448 John D. Baker, Susan J. Bright-Ponte, and Lee Anne M. Palmer 59 Dosage Forms and Veterinary Feed Directives 1459 Geof Smith and Jim E. Riviere 60 Evidence-Based Pharmacotherapy 1465 Ronette Gehring 61 Chemical Residues in Tissues of Food Animals 1469 Jim E. Riviere Index 1481

About the Author

The editors Jim E. Riviere, DVM, PhD, DSc (hon), ATS, is The MacDonald Chair in Veterinary Medicine, University Distinguished Professor, Kansas Bioscience Eminent Scholar, and Director, Institute of Computational Comparative Medicine at Kansas State University in Manhattan, Kansas, USA. He is also a Distinguished Professor Emeritus at North Carolina State University in Raleigh, North Carolina, USA. Mark G. Papich, DVM, MS, Diplomate ACVCP, has the Burroughs Wellcome Professorship in Veterinary Pharmacology and is a Professor of Clinical Pharmacology, Department of Molecular Biomedical Sciences, College of Veterinary Medicine at North Carolina State University in Raleigh, North Carolina, USA.

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