Table of Contents

Preface to the fifth edition vi

Acknowledgements vii

Abbreviations viii

1 The normal bone marrow 1

2 Special techniques applicable to bone marrow diagnosis 61

3 Infection and reactive changes 109

4 Acute myeloid leukaemia mixed phenotype acute leukaemia the myelodysplastic syndromes and histiocytic neoplasms 185

5 Myeloproliferative and myelodysplastic/myeloproliferative neoplasms and related conditions 267

6 Lymphoproliferative disorders 346

7 Plasma cell neoplasms 487

8 Disorders of erythropoiesis granulopoiesis and thrombopoiesis 537

9 Miscellaneous disorders 585

10 Metastatic and non‐haemopoietic tumours 645

11 Diseases of bone 685

Appendix 699

Index 709

About the Author

Barbara J. Bain, MBBS, FRACP, FRCPath, is Professor of Diagnostic Haematology, St Mary's Hospital Campus, Imperial College Faculty of Medicine, and Honorary Consultant Haematologist, St Mary's Hospital, London, UK.

David M. Clark MD, MRCP (UK), FRCPath, is Consultant Haematopathologist, Nottingham University Hospitals NHS Trust, Nottingham and Honorary Clinical Senior Lecturer, Imperial College London.

Bridget S. Wilkins DM, PhD, FRCPath, is Consultant Haematopathologist, Guy's and St Thomas' Hospitals NHS Foundation Trust, London and Hampshire Hospitals NHS Foundation Trust, Winchester, and Honorary Clinical Senior Lecturer, Imperial College London.