A comprehensive collection of cutting-edge research for researchers in the field of nuclear mechanics and genome regulation
Section-A: Cell Nucleus: Organization and MechanoBiology
Fluorescence Fluctuation Microscopy to reveal 3D-Architecture and
Function in the Cell Nucleus
Thorsten Lenser1,2, Klaus Weisshart2, Tobias Ulbricht3, Karolin
Klement3, and Peter Hemmerich
Studying histone modifications and their genomic functions by
employing chromatin immunoprecipitation and immunoblotting
Ranveer S. Jayani, Praveena L. Ramanujam and Sanjeev Galande
Dynamic organization of chromatin assembly & transcription
factories in living cells
Bidisha Sinha, Dipanjan Bhattacharya, Deepak Kumar Sinha, Shefali
Talwar,
Shovamayee Maharana, Soumya Gupta and G. V.Shivashankar
Manipulation & Isolation of Single Cells & Nuclei
Swee Jin Tan, Qingsen Li and Chwee Teck Lim
Beyond lamins: other structural components of the
nucleoskeleton
Zhixia Zhong , Katherine L. Wilson and Kris Noel Dahl
Altered mechanical properties of the nucleus in disease
Maria Lucia Lombardi and Jan Lammerding
Theoretical concepts and models of cellular mechanosensing
Rumi De, Assaf Zemel and Samuel A. Safran
Section-B: Impact of Nuclear Mechanics on Function
Mechanical Induction of Gene Expression in Connective Tissue
Cells
Mathew Chan, Boris Hinz, Christopher A. McCulloch
Physical plasticity of the Nucleus and its manipulation
Irena Ivanovska, Joe Swift, Takamasa Harada, J. David Pajerowski
and Dennis E. Discher
Prestressed Nuclear Organization in Living Cells
Aprotim Mazumder, Roopa T. , Abhishek Kumar, K.Venkatesan Iyer,
Nisha M Ramdas and G. V.Shivashankar
Nanotopography/mechanical induction of stem-cell
differentiation
Evelyn Yim
Mechanical Induction in Embryonic Development and Tumour Growth:
Integrative Cues through Molecular to Multi-cellular Interplay, and
Evolutionary Perspectives
Maria-Elena Fernandez-Sanchez, Fanny Serman, Padra Ahmadi and
Emmanuel Farge
Informatics based analysis of mechanosignaling in the
laminopathies
Frank P.L. Lai, Radfidah A. Mutalif, Siew Cheng Phua, and Colin L.
Stewart
Autosomal Dominant Leukodystrophy caused by lamin B1 duplications:
A clinical and molecular case study of altered nuclear function and
disease
Quasar Saleem Padiath and Ying-Hui Fu
Dr. G. V. Shivashankar is currently the Deputy Director of Mechanobiology Institute, National University of Singapore. Shivashankar’s laboratory is focused on understanding the role of cell geometry on nuclear mechanics and genome regulation in living cells using a multi-disciplinary approach. He carried out his PhD research at the Rockefeller University (1994-1999) and Postdoctoral research at NEC Research Institute, Princeton, USA (1999-2000). He started his laboratory at the National Center for Biological Sciences, TIFR- Bangalore, India (2000-2009) before relocating to a tenured faculty position at the National University of Singapore in 2009. His scientific awards include the Birla Science Prize (2006) and the Swarnajayanthi Fellowship (2007), and he was elected to the Indian Academy of Sciences (2010). He also edited a Methods in Cell Biology volume on Nuclear Mechanics and Genome Regulation (2010), published by Elsevier. More recently, he headed the Joint Research Laboratory with the FIRC Institute of Molecular Oncology (IFOM), Milan, Italy and was appointed as an IFOM-NUS Chair Professor in 2014.
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