Table of Contents

1: RXR: From Partnership to Leadership in Metabolic Regulations

2: The Intersection Between the Aryl Hydrocarbon Receptor (AhR)- and Retinoic Acid-Signaling Pathways

3: Role of Retinoic Acid in the Differentiation of Embryonal Carcinoma and Embryonic Stem Cells

4: Metabolism of Retinol During Mammalian Placental and Embryonic Development

5: Conversion of β-Carotene to Retinal Pigment

6: Vitamin A-Storing Cells (Stellate Cells)

7: Use of Model-Based Compartmental Analysis to Study Vitamin A Kinetics and Metabolism

8: Vitamin A Supplementation and Retinoic Acid Treatment in the Regulation of Antibody Responses In Vivo

9: Physiological Role of Retinyl Palmitate in the Skin

10: Retinoic Acid and the Heart

11: Tocotrienols in Cardioprotection

12: Cytodifferentiation by Retinoids, a Novel Therapeutic Option in Oncology: Rational Combinations with Other Therapeutic Agents

13: Effects of Vitamins, Including Vitamin A, on HIV/AIDS Patients

14: Vitamin A and Emphysema

Index

About the Author

Trained in biochemistry at the University of Wisconsin, Madison, Dr. Litwack worked on enzymology and the effects of hormones on enzyme systems. Then he was a Postdoctoral Fellow of the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. Dr. Litwack's first position was as Assistant Professor of Biochemistry at Rutgers University in 1954. Six years later, he joined the University of Pennsylvania as associate professor and four years later went to the Fels Institute for Cancer Research and Molecular Biology, as full professor, eventually becoming Deputy Director of the Institute. In 1991, he accepted the Chair of Pharmacology at Thomas Jefferson University where he is also Deputy Director of the Jefferson Cancer Institute and Associate Director for Basic Science in the Jefferson Cancer Center. Dr. Litwack's work has been in the area of mechanisms of steroid receptor action involving especially the glucocorticoid and mineralocorticoid receptors, immunophi.