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This comprehensive reference explores-from the perspective of regenerative medicine and tissue engineering-the body's ability to mobilize endogenous stem cells to the site of injury plus the latest strategies for inducing and supporting the body's own regenerating capacity

Table of Contents

1. Fundamentals of In Situ Tissue Regeneration Sang Jin Lee, James J. Yoo and Antony Atala 2. Stem Cell Homing Mariusz Z. Ratajczak and Ahmed A. Ismail 3. Immunology – Host Responses to Biomaterials John D. Jackson

4. Foreign Body Reaction and Stem Cell Responses Ashwin Nair and Liping Tang

5.  Roles of endogenous growth factors and small peptides in in situ tissue regeneration Suna Kim, Hyun Sook Hong and Youngsook Son

6. Small molecules: Controlling cell fate and function Baisong Lu and Anthony Atala

7. Small RNA Delivery for In Situ Tissue Regeneration NaJung Kim, James J. Yoo, Anthony Atala, and Sang Jin Lee 8. Micro and Nano Topographical cues guiding biomaterial host response Deepak M. Kalaskar and Feras Alshomer

9. Mechanobiology and Mechanotherapy in Tissue Engineering Rei Ogawa

10. A biomimetic strategy to design biomaterials for in situ tissue regeneration Ji Hyun Kim and Sang Jin Lee

11. Impact of Matrix Dynamic Properties on Stem Cell Viability Marc B. Taraban1, Yuqi Li, Katherine A. Joyner, Joseph P. Stains and Yihua B. Yu

12. Cell-free Scaffolds for In situ Tissue Regeneration Seung Hun Park, Bo Keun Lee, James Yoo, Sang Jin Lee and Moon Suk Kim

13. In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design T. Konrad Rajab and Harald Ott

14. Synovial Joint: In Situ Regeneration of Osteochondral and Fibrocartilaginous Tissues by Homing of Endogenous Cells Solaiman Tarafder and Chang H. Lee

15. Bioengineered strategies for tendon regeneration Ana I. Gonçalves, Márcia T. Rodrigues, Rui L. Reis and Manuela E. Gomes

16. Volumetric Muscle Repair In Situ Lindsey E. Shapiroa, Ji Hyun Kima, In Kap Ko, Sang Jin Lee,  James J. Yoo and Anthony Atalaa

17. Mending The Heart Through In Situ Cardiac Regeneration Jeremy Choon Meng Teo, Selwa Mokhtar Boularaoui, Noaf Salah Ali AlWahab and Nicolas Christoforou

18. Skin Wound Healing – Skin Regeneration with Pharmacological Mobilized Stem Cells Zhaoli Sun and George Melville Williams

19. In situ renal regeneration Hung-Jen Wang, Sang Jin Lee, Anthony Atala and James J. Yoo

20. Regulatory Aspects: regulation aspects of cell-free biomaterial implants Nan Zhang, Alexander Baume, Richard Payne, Julie Allickson

21. Business Perspective – case study:  commercialized cell-free cardiovascular implant Alexander Sheehy, Byron Lambert and Richard Rapoza

About the Author

Assistant Professor, Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine, and the W. Boyce Professor and Chair of Urology. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. Fifteen applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is Editor of 25 books and 3 journals. Dr. Atala has published over 800 journal articles and has received over 250 national and international patents. Dr. Atala was elected to the Institute of Medicine of the National Academies of Sciences, to the National Academy of Inventors as a Charter Fellow, and to the American Institute for Medical and Biological Engineering.

Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, the National Institutes of Health Bioengineering Consortium, and the National Cancer Institute’s Advisory Board. He is a founding member of the Tissue Engineering Society, Regenerative Medicine Foundation, Regenerative Medicine Manufacturing Innovation Consortium, Regenerative Medicine Development Organization, and Regenerative Medicine Manufacturing Society. Professor, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC