Table of Contents

1: Introduction
2: Electron Microscopy of Macromolecular Assemblies
3: Two-Dimensional Averaging Techniques
4: Multivariate Data Analysis and Classification of Images
5: Three-Dimensional Reconstruction
6: Interpretation of Three-Dimensional Images of Macromolecules
Appendix 1: Some Important Definitions and Theorems
Appendix 2: Profiles, Point-Spread Functions, and Effects of Commonly Used Low-Pass Filters
Appendix 2: Bibliography of Methods
Appendix 2: Bibliography of Structures
Appendix 2: Special Journal Issues on Image Processing Techniques

About the Author

Joachim Frank is an Investigator at the Howard Hughes Medical Institute. He is also Professor of Biomedical Sciences and Adjunct Professor of Biology at the State University of New York at Albany, Adjunct Professor of Biochemistry and Molecular Biophysics at Columbia University, Research Professor of Cell Biology at New York State University Medical School, and head of the Laboratory of Computational Biology and Macromolecular Imaging at Health
Research, Inc., the Wadsworth Center.