Contributors xv
Preface xix
1 Natural Products in Drug Discovery: Recent Advances 1
Gordon M. Cragg, Paul G. Grothaus, and David J. Newman
2 Modern Approaches in the Search for New Active Compounds from
Crude Extracts of Natural Sources 43
Emerson F. Queiroz, Kurt Hostettmann, and Jean-Luc Wolfender
3 Natural Products as Lead Compounds in Medicinal Chemistry
81
Eliezer J. Barreiro, Carlos A. M. Fraga, and Lidia M. Lima
4 The Importance of Structural Manipulation of Natural Compounds
in Drug Discovery and Development 127
Arturo San Feliciano, María Á. Castro, José L. López-Pérez, and
Esther del Olmo
5 The Action of Plants and their Constituents on the Central
Nervous System 161
Fúlvio R. Mendes, Giuseppina Negri, Joaquim M. Duarte-Almeida,
Ricardo Tabach, and Elisaldo A. Carlini
6 The Role of Natural Products in Discovery of New
Anti-Infective Agents with Emphasis on Antifungal Compounds 205
Maximiliano Sortino, Marcos Derita, Laura Svetaz, Marcela Raimondi,
Melina Di Liberto, Elisa Petenatti, Mahabir Gupta, and Susana
Zacchino
7 Antiulcer Agents from Higher Plants 241
Luiz C. Klein-Júnior, José R. Santin, and Sérgio F. de Andrade
8 Recent Progress in the Chemistry and Biology of Paclitaxel
(TaxolTM) and Related Taxanes 263
Jun Qi, Jielu Zhao, and David G. I. Kingston
9 Cancer Chemopreventive Activity of Higher Plants 337
A. Douglas Kinghorn, Yulin Ren, Jie Li, and Chung Ki Sung
10 Medicinal Plants and Pharmaceutical Technology 359
Ruth M. Lucinda da Silva, Angélica G. Couto, and Tania M.B.
Bresolin
11 Natural Products in Clinical Trials 395
Sigrun Chrubasik
12 The Influence of Biotic and Abiotic Factors on the Production
of Secondary Metabolites in Medicinal Plants 419
Dayana R. Gouvea, Leonardo Gobbo-Neto, and Norberto P. Lopes
13 Production of Bioactives Compounds: The Importance of
Pictet–Spengler Reaction in the XXI Century 453
Pilar Menendez, Ilaria D’Acquarica, Giuliano Delle Monache,
Francesca Ghirga, Andrea Calcaterra, Marco Barba, Alberto Macone,
Alberto Boffi, Alessandra Bonamore, and Bruno Botta
14 Screening Methods for Drug Discovery from Plants 489
Alan L. Harvey
15 Phytotherapeutics – Intellectual Property Rights, Global
Market, and Global Regulatory Guidelines 499
James D. McChesney, Raymond Cooper, and Kip Vought
16 Cooperation Between the Pharmaceutical Industry and Academic
Institutions in Drug Discovery 529
Valdir Cechinel-Filho, Rivaldo Niero, and Rosendo A. Yunes
Acknowledgments 542
References 542
Index 545
Valdir Cechinel-Filho, PhD, is Professor and Researcherat the Chemical-Pharmaceutical Investigations Center, University ofVale do Itajai in Brazil. The editor of five books, seventeencontributed chapters, and over 250 scientific papers and reviews,Dr. Filho is also Associate Editor of PharmaceuticalBiology, a member of the editorial boards of several journals,and a reviewer for many journals, including European Journal ofMedicinal Chemistry, Journal of Pharmacy andPharmacology, Natural Product Research, PlantaMedica, and Journal of Agricultural and FoodChemistry.
In conclusion, this book could be a useful guide not onlyfor PhD students starting their activity in the field of plantmetabolites, but also for more advanced researchers looking for astate-of-the-art overview of modern research in this fascinatingfield. (ChemMedChem, 1 March 2013)
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