Table of Contents

1. Introduction; Part I. Glycolytic Oscillations: 2. Oscillatory enzymes: simple periodic behaviour in an allosteric model for glycolytic oscillations; Part II. From Simple to Complex Oscillatory Behaviour; 3. Birhythmicity: coexistence between two stable rhythms; 4. From simple periodic behaviour to complex oscillations, including bursting and chaos; Part III. Oscillations Of Cyclic Amo In Dictyostelium Cells: 5. Models for the periodic synthesis and relay of camp signals in Dictyostelium discoideum amoebae; 6. Complex oscillations and chaos in the camp signalling system of Dictyostelium; 7. The onset of camp oscillations in Dictyostelium as a model for the ontogenesis of biological rhythms; Part IV. Pulsatile Signalling In Intercellular Communication: 8. Function of the rhythm of intercellular communication in Dictyostelium. Link with pulsatile hormone secretion; Part V. Calcium Oscillations: 9. Oscillations and waves of intracellular calcium; Part VI. The Mitotic Oscillator: 10. Modelling the mitotic oscillator driving the cell division cycle; Part VII. Circadian Rhythms: 11. Towards a model for circadian oscillations in the Drosophila period protein (PER); 12. Conclusions and perspectives; References.

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Reviews

'The book beautifully illustrates the art of modelling ... The author has been studying the theory of oscillations and rhythms for 25 years and brings a great deal of experience to bear on this book ... It is an excellent read and will appeal to a wide-ranging audience, from students moving into the area to established researchers in the field, and from mathematical modellers to experimentalists in the life sciences.' Trends in Biochemical Sciences '... an extraordinarily impressive volume. I am fully confident that it will be the definitive work in this area for years to come.' Paul Rapp, Professor of Physiology, Medical College of Pennsylvania 'It really is a very impressive tome and is a superb addition to the literature. It is quite clearly going to be the reference book on oscillations.' James D. Murray, Professor of Applied Mathematics and Mathematical Biology, University of Washington, Seattle