1. Historical Principles and Perspectives
Paul M. Wax
2. Toxicologic Misfortunes and Catastrophes in History
Paul M. Wax
PART A
THE GENERAL APPROACH TO THE PATIENT
3. Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes
Lewis S. Nelson, Mary Ann Howland, Neal A. Lewin, Lewis R. Goldfrank and Robert S. Hoffman
4. Principles of Managing the Acutely Poisoned or Overdosed Patient
Lewis S. Nelson, Mary Ann Howland, Neal A. Lewin, Lewis R. Goldfrank and Robert S. Hoffman [include eCPR, critical care dispositions]
SC1. Principles of Antidote Stocking
[Insert author(s)]
5. Decontamination Principles: Prevention of Gastrointestinal Absorption
Lotte C. G. Hoegberg and Anne-Bolette Gude
SC2. Decontamination Principles: Prevention of Dermal, Inhalational and Ocular Absorption
[Insert author(s)]
A1. Activated Charcoal
Silas W. Smith and Mary Ann Howland
A2. Whole-Bowel Irrigation and Other Intestinal Evacuants
Silas W. Smith and Mary Ann Howland
6. Principles and Techniques Applied to Enhance Elimination
David S. Goldfarb and Marc Ghannoum
7. Laboratory Principles
Petrie M. Rainey
8. Principles of Diagnostic Imaging
David T. Schwartz
9. Pharmacokinetic and Toxicokinetic Principles
Mary Ann Howland
PART B
THE FUNDAMENTAL PRINCIPLES OF MEDICAL TOXICOLOGY
SECTION I
BIOCHEMICAL AND MOLECULAR CONCEPTS
10. Chemical Principles
Stephen J. Traub and Lewis S. Nelson
11. Biochemical and Metabolic Principles
Kurt C. Kleinschmidt and Kathleen A. Delaney
12. Fluid, Electrolyte, and Acid–Base Principles
Alan N. Charney and Robert S. Hoffman
13. Neurotransmitters and Neuromodulators
Steven C. Curry, Ayrn D. O’Connor, Kimberlie A. Graeme, Kirk C. Mills, and Aaron B. Skolnik
14. Withdrawal Principles
Richard J. Hamilton and [new author]
SECTION II
PATHOPHYSIOLOGIC BASIS: ORGAN SYSTEMS
15. Cardiologic Principles I: Electrophysiologic and Electrocardiographic Principles
Cathleen Clancy
16. Cardiologic Principles II: Hemodynamics
[new author] and Robert A. Hessler
17. Dermatologic Principles
Jesse M. Lewin, Neal A. Lewin, and Lewis S. Nelson
SC3. Transdermal Toxicology
Lewis S. Nelson
18. Gastrointestinal Principles
Matthew D. Zuckerman and Richard J. Church
19. Genitourinary Principles
Jason Chu
20. Hematologic Principles
Marco L.A. Sivilotti
21. Hepatic Principles
Kathleen A. Delaney
22. Neurologic Principles
Rama B. Rao
23. Oncologic Principles
Richard Wang
24. Ophthalmic Principles
Adhi Sharma
25. Otolaryngologic Principles
[new author] and William Chiang
26. Psychiatric Principles
Erin A. Zerbo and Andr ea M. Kondracke
27. Renal Principles
Marc Ghannoum and David S. Goldfarb
28. Respiratory Principles
Andrew Stolbach and Robert S. Hoffman
29. Thermoregulatory Principles
Susi U. Vassallo and Kathleen A. Delaney
SECTION III
SPECIAL POPULATIONS
30. Reproductive and Perinatal Principles
Jeffrey S. Fine
31. Pediatric Principles
Jeffrey S. Fine
32. Geriatric Principles
Judith C. Ahronheim and Mary Ann Howland
PART C
THE CLINICAL BASIS OF MEDICAL TOXICOLOGY
SECTION I
A. ANALGESICS AND ANTIINFLAMMATORY MEDICATIONS
Case Study 1
33. Acetaminophen
Robert G. Hendrickson
A3. N-Acetylcysteine
Robert G. Hendrickson and Mary Ann Howland
34. Colchicine, Podophyllin, and the Vinca Alkaloids
Joshua G. Schier
35. Nonsteroidal Antiinflammatory Drugs
William J. Holubek
36. Opioids
Lewis S. Nelson and Dean Olsen
A4. opioid antagonists
Lewis S. Nelson and Mary Ann Howland
SC4. Internal Concealment of Xenobiotics
Jane M. Prosser
SC5. Harm Reduction for Opioid Overdose
?Josh Lee
37. Salicylates
Daniel M. Lugassy
A5. sodium bicarbonate
Paul M. Wax
B. Food, Diet, and Nutrition
CASE STUDY 2
38. Botulism
Howard L. Geyer
A6. botulinum antitoxin
Silas W. Smith and Howard L. Geyer
39. Food Poisoning
[new author]and Michael Tunik
40. Dieting Xenobiotics and Regimens
Jeanna M. Marraffa
41. Athletic Performance Enhancers
Susi U. Vassallo
42. Essential Oils
Lauren Kornreich Shawn
43. Herbal Preparations
[new author] and Oliver Hung
44. Vitamins
Beth Y. Ginsburg
45. Iron
Jeanmarie Perrone
A7. deferoxamine
Mary Ann Howland
C. pharmaceuticals
case study 3
46. Pharmaceutical Additives
Sean P. Nordt and Lisa E. Vivero
47. Antidiabetics and Hypoglycemics/Antiglycemics
George M. Bosse
A8. Dextrose (d-Glucose)
[new author] and Larissa Velez
A9. octreotide
Mary Ann Howland and Silas W. Smith
48. Antiepileptics
Suzanne Doyon
A10. l-carnitine
Mary Ann Howland
49. Antihistamines and Decongestants
Sophie Gosselin
A11. physostigmine salicylate
Mary Ann Howland
50. Chemotherapeutics
Richard Y. Wang
51. Methotrexate, 5-Flourouracil, and Capecitabine
Richard Y. Wang
A12. folates: leucovorin (Folinic acid) and Folic Acid
Mary Ann Howland
A13. glucarpidase (carboxypeptidase g2)
Silas W. Smith
A14. uridine triacetate
Silas W. Smith
SC6. Inadvertent Intrathecal Administration of Xenobiotics
Rama B. Rao
SC7. Extravasation of Chemotherapeutics
Richard Y. Wang
52. Antimigraine Medications
Jason Chu
53. Thyroid and Antithyroid Medications
Nicole C. Bouchard
D. Antimicrobials
54. Antibacterials, Antifungals, and Antivirals
Christine M. Stork
55. Antimalarials
James David Barry
56. Antituberculous Medications
Christina H. Hernon
A15. pyridoxine
Mary Ann Howland
E. Cardiopulmonary Medications
CASE STUDY 4
57. Antidysrhythmics
Lewis S. Nelson
A16. Magnesium Sulfate
Silas Smith
58. Antithrombotics
Betty C. Chen and Mark Su
A17. Protein Complex Concentrate and novel Antithrombotic Antidotes
[Insert author(s)], Betty Chen and Mark Su
A18. Vitamin k1
Mary Ann Howland
A19. protamine
Mary Ann Howland
59. β-Adrenergic Antagonists
Jeffrey R. Brubacher
A20. Glucagon
Mary Ann Howland
60. Calcium Channel Blockers
David H. Jang and Francis Jerome DeRoos
A21. High-dose insulin euglycemia
Samuel J. Stellpflug and William Kerns, II
61. Miscellaneous Antihypertensives and Pharmacologically Related Agents
Francis Jerome DeRoos
62. Cardioactive Steroids
Jason B. Hack
A22. digoxin-specific antibody fragments
Mary Ann Howland
63. Methylxanthines and Selective β2-Adrenergic Agonists
Robert J. Hoffman
F. ANESTHETICS AND RELATED MEDICATIONS
64. Local Anesthetics
David R. Schwartz and Brian Kaufman
A23. intravenous lipid emulsion
[new author] and Todd Bania
65. Inhalational Anesthetics
Brian Kaufman
66. Neuromuscular Blockers
Kenneth M. Sutin
A24. dantrolene sodium
Kenneth M. Sutin
A25. Sugammadex
[new; Author]
G. Psychotropics
CASE STUDY 5
67. Antipsychotics
David Juurlink
68. Cyclic Antidepressants
Erica L. Liebelt
69. Serotonin Reuptake Inhibitors and Atypical Antidepressants
Christine M. Stork
70. Lithium
Howard A. Greller
71. Monoamine Oxidase Inhibitors
Alex F. Manini
72. Sedative-Hypnotics
David C. Lee
A26. flumazenil
Mary Ann Howland
H. SUBSTANCES OF ABUSE
CASE STUDY 6
73. Amphetamines
; David H. Jang
74. Cannabinoids
Jeff M. Lapoint
75. Cocaine
Jane M. Prosser and Robert S. Hoffman
A27. Benzodiazepines
Robert S. Hoffman, Lewis S. Nelson, and Mary Ann Howland
76. Ethanol
Luke Yip
A28. Thiamine hydrochloride
Robert S. Hoffman
77. Ethanol Withdrawal
Jeffrey A. Gold and Lewis S. Nelson
78. Disulfiram and Disulfiram-like Reactions
Amit K. Gupta
79. <
Mary Ann Howland, PharmD, DABAT, FAACT Clinical Professor of
Pharmacy, St. Johns University College of Pharmacy; Consultant,
Department of Emergency Medicine, Bellevue Hospital Center and New
York University Medical Center; Senior Consultant in Residence, New
York City Poison Center, New York, New York.
McGraw-Hill authors represent the leading experts in their fields
and are dedicated to improving the lives, careers, and interests of
readers worldwide
McGraw-Hill authors represent the leading experts in their fields
and are dedicated to improving the lives, careers, and interests of
readers worldwide
McGraw-Hill authors represent the leading experts in their fields
and are dedicated to improving the lives, careers, and interests of
readers worldwide
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