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Table of Contents

I. Basic Aspects of Oncogenes in Malignant Transformation.- 1. Oncogenes and proto-oncogenes: General concepts.- 2. Molecular biology: Concepts and techniques.- 3. The myc family of nuclear proto-oncogenes.- 4. The ras family of oncogenes.- 5. src-related protein tyrosine kinases.- 6. The epidermal growth factor receptor and its ligands.- 7. The platelet-derived growth factor system.- 8. Transforming growth factors-? and -? and their potential roles in neoplastic transformation.- II. Clinical Aspects of Oncogenes in Human Neoplasia.- 9. Oncogenes in human solid tumors.- 10. Oncogenes in human leukemias and lymphomas.- 11. Human retrovirus-associated malignancy.- 12. The human DNA tumor viruses: Human papilloma virus and Epstein-Barr virus.- 13. Molecular biology of the human retinoblastoma gene.- 14. Therapeutic applications of oncogenes.

Reviews

'This book contains several outstanding reviews and important perspectives in a field that seems to be changing every year. It is an important contribution that many people would find useful to review and have on their shelves.' Breast Cancer Research and Treatment 19 1991