Table of Contents

Genetic aspects.- Determination of regions important for Monoamine Oxidase (MAO) A and B substrate and inhibitor selectivities.- Monoamine oxidase A deficiency: biogenic amine metabolites in random urine samples.- Relationship between monoamine oxidase (MAO) A specific activity and proportion of human skin fibroblasts which express the enzyme in culture.- Are MAO-A deficiency states in the general population and in putative high-risk populations highly uncommon?.- Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline).- Clinical aspects.- Experience with tranylcypromine in early Parkinson’s disease.- Deprenyl monotherapy improves visuo-motor control in early parkinsonism.- Endogenous monoamine oxidase A inhibitory activity (tribulin), measured in saliva, is related to cardiovascular reactivity in normal individuals.- MAO inhibitory side effects of neuroleptics and platelet serotonin content in schizophrenic patients.- Neuroprotection.- Modulation of glutamate neurotoxicity in the transformed cell culture by monoamine oxidase inhibitors, clorgyline and deprenyl.- A cell culture model of cerebral ischemia as a convenient system to screen for neuroprotective drugs.- Neuroprotection by selegiline and other MAO inhibitors.- The neuroprotective and neuronal rescue effects of (—)-deprenyl.- Oxidation of Nmethyl (R)salsolinol: involvement to neurotoxicity and neuroprotection by endogenous catechol isoquinolines.- Biochemistry of monoamine oxidases.- Substrate regulation of monoamine oxidase.- Monoamine oxidases and related amine oxidases as phase I enzymes in the metabolism of xenobiotics.- Monoamine oxidases: from brain maps to physiology and transgenics to pathophysiology.-Structure-function relationships of mitochondrial monoamine oxidase A and B: chimaeric enzymes and site-directed mutagenesis studies.- Deamination of methylamine and angiopathy; toxicity of formaldehyde, oxidative stress and relevance to protein glycoxidation in diabetes.- Monoamine oxidase activities in human cystic and colonic arteries — influence of age.- Influence of maturation and ageing on the biotransformation of noradrenaline in the rat.- The oxidation of dopamine and epinine by the two forms of monoamine oxidase from rat liver.- Biochemistry of semicarbazide-sensitive amine oxidase.- Properties and functions of tissue-bound semicarbazide-sensitive amine oxidases in isolated cell preparations and cell cultures.- Studies on the time-dependent activation of microsomal semicarbazide-sensitive amine oxidas.- Studies on the behaviour of semicarbazide-sensitive amine oxidase in Sprague-Dawley rats treated with the monoamine oxidase inhibitor tranylcypromine.- Semicarbazide-sensitive amine oxidase in pig heart.- Pharmacology of MAO inhibitors.- Chronic TVP-1012 (rasagiline) dose — activity response of monoamine oxidases A and B in the brain of the common marmoset.- Increased striatal dopamine production from L-DOPA following selective inhibition of monoamine oxidase B by R(+)-N-propargyl-l-amino-indan (rasagiline) in the monkey.- Effects of N-propargyl-l-(R)aminoindan (rasagiline) in models of motor and cognition disorder.- (R)(+)-N-Propargyl-l-aminoindan (rasagiline) and derivatives: highly selective and potent inhibitors of monoamine oxidase B.- Function of endogenous monoamine oxidase inhibitors (tribulin).- Long term administration of (—)-deprenyl increases mortality in male Wistar rats.- Selegiline as immunostimulant — a novel mechanism of action?.-Clorgyline effect on pineal melatonin biosynthesis in rats with lesioned suprachiasmatic nuclei.- The effect of MAO-A inhibition and cold-immobilization stress on N-acetylserotonin and melatonin in SHR and WKY rat.- The influence of the antidepressant pirlindole and its dehydro-derivative on the activity of monoamine oxidase A and GABAA receptor binding.- “In vitro” effect of some 5-hydroxy-indolalkylamine derivatives on monoamine uptake system.- N-Alkyloxycarbonyl derivatives of ethylene diamine as monoamine oxidase inhibitors.

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"... the book is of particular value and a rich source of information for basic neuroscientists in the field. But it also can be of substantial interest to the rest of the neuroscientific community to get a glimpse of the current status of research in the field of MAO.” Acta Neurologica Belgica