Table of Contents

Nicotine and Tobacco Consumption: Measurement and Trends.- Global Patterns of Nicotine and Tobacco Consumption.- Nicotine Chemistry, Metabolism, Kinetics and Biomarkers.- Nicotine Content and Delivery Across Tobacco Products.- Nicotine Pharmacology and Mechanisms of Action.- The Road to Discovery of Neuronal Nicotinic Cholinergic Receptor Subtypes.- Magnetic Resonance Imaging Studies of Cigarette Smoking.- In vivo Brain Imaging of Human Exposure to Nicotine and Tobacco.- Molecular and Cellular Mechanisms of Action of Nicotine in the CNS.- The Neuronal Pathways Mediating the Behavioral and Addictive Properties of Nicotine.- Molecular Genetics of Nicotine Metabolism.- Sex Differences in Nicotine Action.- Nicotine Psychopharmacology.- Recognising Nicotine: The Neurobiological Basis of Nicotine Discrimination.- Effects of Nicotine in Experimental Animals and Humans: An Update on Addictive Properties.- Discriminative Stimulus Effects of Nicotine in Humans.- Rodent Models of Nicotine Withdrawal Syndrome.- Approaches, Challenges, and Experience in Assessing Free Nicotine.- Approaches, Challenges, and Experience in Assessing Free Nicotine.- Tobacco Industry Manipulation of Nicotine Dosing.- Pharmacotherapy for Tobacco Dependence.- Nicotine Psychopharmacology: Policy and Regulatory.