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Table of Contents

Section I Chemistry, biology and microbiologic action of tetracyclines (Editor: Mark L. Nelson).- The chemistry and cellular biology of the tetracyclines.- Proton and metal ion binding of tetracyclines.- Section II Tetracycline-dependent gene regulation: A versatile tool for all organisms (Editor: Wolfgang Hillen).- Gene regulation by the tetracycline-inducible Tet repressor-operatorsystem – molecular mechanisms at atomic resolution.- Regulation of gene expression in yeast and plants by tetracycline-dependent regulatory systems.- Tetracyclines in the control of gene expression in eukaryotes.- Tetracycline-regulated gene expression to study oncogenes in vivo..- Interactions of tetracyclines with RNA.- Section III Use of tetracyclines as non-antimicrobial medicinal agents (Editor: Robert A. Greenwald).- Biologic, non-antibiotic properties of semi-synthetic and chemically modified tetracyclines – a structured, annotated bibliography.- Tetracycline consumption in prehistory.- Tetracycline treatment of periodontal disease: antimicrobial and non-antimicrobial mechanisms.- Inhibition of matrix metalloproteinases (MMPs) by tetracyclines.- Structure/function studies of doxycycline effects on matrixmetalloproteinase activity and cartilage degeneration.- Regulation of inflammatory mediators by tetracyclines.- Tetracyclines and autoimmunity.- Tetracycline photodynamics.