Table of Contents

Enkephalins-Endorphins: Stress and the Immune System.- Introduction: The Ying-Yang Hypothesis of Immunomodulation.- Stress and the Immune System.- Candidate Opioid Peptides for Interaction with the Immune System.- Control Mechanisms in the Enzyme Hydrolysis of Adrenal-Released Enkephalins.- Studies of the Endogenous Opioid System in the Human Stress Response.- Exercise Stress and Endogenous Opiates.- Effects of Coping and Noncoping with Stressful Events on the Immune System.- Depression, Hormones and Immunity.- Endogenous Opiod Systems, Stress, and Cancer.- Effects of Stress and Morphine on Natural Killer Cell Activity and on the Mammary Tumor Development.- Endocrine and Immunological Responses to Acute Stress.- Regulatory Circuits of the Immune, Endocrine and Nervous System.- A Complete Regulatory Loop Between the Immune and Neuroendocrine Systems Operates Through Common Signal Molecules (Hormones) and Receptors.- Endorphins: A Link Between Personality, Stress, Emotions, Immunity, and Disease?.- Involvement of Non-Opiate Peptides in Psychoneuroimmunological Modulations.- Regulation of Human Cellular Immune Responses by Glucocorticosteriods.- Estrogen-Mediated Immunomodulation.- Effects on the Immune System of Lesioning and Stimulation of the Nervous System: Neuroimmunomodulation.- Effects of Enkephalins/Endorphins and Related Substances on Specific Immune Functions.- Enkephalins: Mediators of Stress-Induced Immunomodulation.- Relationship Between Lymphokine and Opiatergic Modulation of Lymphocyte Proliferation.- Enkephalins as Molecules of Lymphocyte Activation and Modifiers of the Biological Response.- The Influence of Endogenous Opioid Peptides on Venous Granulocytes.- Immunosuppressive Effects of the Opiopeptins.- T-Cell E-Receptor Modulation By Opiates, Opiods and Other Behaviorally Active Substances.- Significant Role of Receptor Coupling in the Neuropeptide-Induced Alterations of Macrophage Cytotoxicity.- Hormonal Modulation of the Human Autologous Mixed Lymphocyte Reaction.- Implications Involving Autoimmune Mechanisms to the PCP Receptor in Schizophrenia.- Effects of Morphine Opiates on Immune Function.- Opioid Peptide Effects on Leukocyte Migration.- Neuropeptides are Chemoattractants for Human Monocytes and Tumor Cells: A Basis for Mind-Body Communication.- Early Clinical Trials of Methionine Enkephalin(In Vivo).- Methionine Enkephalin: Immunomodulator in Normal Volunteers (In Vivo).- Methionine Enkephalin: Clinical Pharmacology.- Methionine Enkephalin: T-Cell Enhancement in Normal Volunteers (In Vivo).- Methionine Enkephalin: Enhancement of T-Cells in Patients with Kaposis’ Sarcoma, AIDS, and Lung Cancer (In Vivo).- Epilogue.- Contributors.