Table of Contents

List of contributors, vii

Preface, ix

List of abbreviations, x

About the companion website, xv

Part 1: Solid tumors

1 Rhabdomyosarcoma, 3
Katherine K. Matthay

(Commentary by Meriel Jenney)

2 Osteosarcoma, 14
Katherine K. Matthay

(Commentary by Maria Michelagnoli)

3 Ewing sarcoma, 25
Katherine K. Matthay

(Commentary by Steven G. DuBois)

4 Wilms tumor, 34
Ananth Shankar

(Commentary by Kathy Pritchard-Jones)

5 Neuroblastoma, 47
Katherine K. Matthay

(Commentary by Katherine K. Matthay)

6 Hepatoblastoma, 58
Ross Pinkerton

(Commentary by Penelope Brock)

7 Malignant germ cell tumors, 65
Ross Pinkerton

(Commentary by Ross Pinkerton)

8 Medulloblastoma, 69
Ross Pinkerton

(Commentary by Eric Bouffet)

9 Glioma, 81
Ross Pinkerton

(Commentary by Joann L. Ater)

10 Non-Hodgkin lymphoma, 88
Ross Pinkerton

(Commentary by Ross Pinkerton)

11 Hodgkin lymphoma, 105
Ross Pinkerton

(Commentary by Cindy L. Schwartz)

Part 2: Leukemia

Section 1: Acute myeloid leukemia 12 Acute myeloid leukemia commentary, 119
Robert J. Arceci

13 Remission induction in acute myeloid leukemia, 126
Ananth Shankar

14 Acute myeloid leukemia consolidation, 135
Ananth Shankar

15 Maintenance treatment in acute myeloid leukemia, 137
Ananth Shankar

16 Autologous bone marrow transplantation in acute myeloid leukemia, 141
Ananth Shankar

17 Acute myeloid leukemia: miscellaneous, 144
Ananth Shankar

Section 2: Childhood lymphoblastic leukemia

18 Childhood lymphoblastic leukemia commentary, 146
Vaskar Saha

19 Remission induction in childhood lymphoblastic leukemia, 154
Ananth Shankar

20 Central nervous system-directed therapy in childhood lymphoblastic leukemia, 168
Ananth Shankar

21 Maintenance treatment in childhood lymphoblastic leukemia, 180
Ananth Shankar

22 Relapsed childhood lymphoblastic leukemia, 198
Ananth Shankar

23 Postinduction therapy in adolescents and young adults with acute lymphoblastic leukemia, 204
Ananth Shankar

Part 3: Supportive care in pediatric oncology

24 Colony-stimulating factors, 209
Ananth Shankar

(Commentary by Victoria Grandage)

25 Cardioprotection in pediatric oncology, 230
Ananth Shankar

(Commentary by Gill A. Levitt)

26 Infections in pediatric and adolescent oncology, 243
Ananth Shankar and Sara Stoneham

(Commentary by Julia E. Clark)

Index, 269

About the Author

Edited by Ross Pinkerton, MB, BCh, BaO, MD, Executive Director,Division of Oncology, Royal Children s Hospital,Children s Health Queensland, Brisbane, QLD, Australia Ananth Shankar, MD, FRCPCH, Consultant in Paediatric andAdolescent Oncology, University College London Hospitals NHS Foundation Trust, London, UK Katherine K. Matthay, BA, MD, Mildred V. StroussProfessor of Translational Oncology, Director, PediatricHematology-Oncology, Department of Pediatrics, UCSF School ofMedicine and UCSF Benioff Children s Hospital, San Francisco,CA, USA