Table of Contents

• Introduction
• From Immunotherapy of Cancer to Genetic Studies of Lung and Kidney Cancer
• Preliminary Genetic Studies
• von Hippel–Lindau Disease
• Chromosome 3 Translocation Families
• Hereditary Papillary Renal Carcinoma
• The “Open Door” Policy in the Urologic Oncology Clinic of the National Cancer Institute Birt-Hogg-Dube Syndrome
• The Birt–Hogg–Dube Syndrome
• Hereditary Leiomyoma Renal Cell Carcinoma
• Succinate Dehydrogenase Gene Mutations and Renal Carcinoma
• Tuberous Schlerosis and Renal Carcinoma
• Affection Status and Linkage Analysis
• Revisiting the National Cancer Institute Urologic Oncology Branch Collection of Renal Cancer Families to Identify Germline Mutations in Renal Carcinoma Genes in Previously Accessioned Families. Time between Family Accession and Germline Mutation Detection. Detection of Germline Mutations in Families with Single, Living Affected Individuals
• Recent Discoveries in Human Renal Cancer Genetics
• Use of Next-Generation DNA Sequencing to Study the Genetic Basis of Human Renal Cell Carcinomas
• Conclusion
• References