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Modern Therapeutics in Rheumatic Diseases
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Leading clinicians and clinical researchers discuss in practical detail the newest treatments used in rheumatic diseases, emphasizing-without neglecting current standard treatments-those experimental therapies now undergoing clinical trials and poised for early introduction into the rheumatology armamentarium. The diseases and therapeutic regimes examined here range from rheumatoid arthritis and its treatment by gene therapy, to osteoarthritis and systemic autoimune diseases. Each chapter is organized so that the busy clinician can quickly obtain all the information needed optimal patient treatment. This includes an analysis of the pathogenic mechanisms that explain the molecular basis of the newer therapeutics, reviews of animal data and the results of clinical trials, and recommendations concerning use, side effects, and precautions.
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Table of Contents

I. Rheumatoid Arthritis Larry W. Moreland, Section Editor New Treatment Opportunities for Rheumatoid Arthritis Larry W. Moreland Genetic Influences on Treatment Response in Rheumatoid Arthritis S. Louis Bridges, Jr. and Robert P. Kimberly Nonsteroidal Anti-Inflammatory Drugs in the Treatment of Rheumatoid Arthritis John S. Sundy Additional Considerations on the Use of Nonsteroidal Anti-Inflammatory Drugs M. Elaine Husni and Lee S. Simon Glucocorticoid Therapy in Rheumatoid Arthritis Kenneth G. Saag and John R. Kirwan Anti-Tumor Necrosis Factor Agents Alan K. Matsumoto and Joan M. Bathon Interleukin-1 Receptor Antagonist Treatment in Rheumatoid Arthritis Barry Bresnihan Leflunomide: An Immunomodulatory Drug for the Treatment of Rheumatoid Arthritis Paul Emery, David L. Scott, and Vibeke Strand Matrix Metalloproteinase Inhibitors as Therapies for Rheumatoid Arthritis Sean J. Wollaston and Kenneth C. Kalunian Combination Disease-Modifying Anti-Rheumatic Drug (DMARD) Therapy James R. O'Dell Experimental Therapeutics for Rheumatoid Arthritis Mark C. Genovese and William H. Robinson II. Osteoarthritis Jean-Pierre Pelletier and Johanne Martel-Pelletier, Section Editors Slow-Acting Drugs for the Treatment of Osteoarthritis Jean-Yves Reginster and Roy D. Altman Intra-Articular Therapy in Ostheoarthritis Boulos Haraoui and Jean-Pierre Raynauld Promoting Articular Cartilage Repair Joseph A. Buckwalter and James A. Martin Using Molecular Markers to Monitor Osteoarthritis Ivan G. Otterness and Mary J. Saltarelli New Therapeutic Targets for Osteoarthritis: The Rewards of Research Jean-Pierre Pelletier, Johanne Martel-Pelletier, and Pamela Manning Recent Developments in the Therapy of Osteoarthritis Jean-Pierre Pelletier and Johanne Martel-Pelletier III. Systemic Autoimmune Diseases Gary M. Kammer and George C. Tsokos, Section Editors Treatment of Systemic Lupus Erythematosus Peter H. Schur and Gary M. Kammer Treatment of the Antiphospholipid Syndrome Joan T. Merrill Treatment of Systemic Lupus Erythematosus by Blocking T-Cell Costimulation David I. Daikh and David Wofsy Current Management of Systemic Sclerosis Clarence W. Legerton III and Richard M. Silver Sjoegren's Syndrome Robert W. Hoffman and Eric L. Greidinger Mixed Connective Tissue Disease Robert W. Hoffman and Eric L. Greidinger Vasculitis Dimitrios Vassilopoulos and Leonard H. Calabrese Treatment of Juvenile Rheumatoid Arthritis Laura J. Mirkinson and Ildy M. Katona Treatment of Inflammatory Myopathies William R. Gilliland Psoriatic Arthritis Dimitrios T. Boumpas and Gabor G. Illei Complement Inhibitors in Rheumatic Diseases Sherry D. Fleming and George C. Tsokos Hematopoietic Stem Cell Transplantation of Autoimmune Disease Richard K. Burt and Ann E. Traynor IV. Gene Therapy in Rheumatic Diseases Steffen Gay, Section Editor Vectors for Gene Delivery Sandro Rusconi and Maurizio Ceppi Gene Targeting of Cytokines and the Mitogen-Activated Protein Kinase Pathways in Human Rheumatoid Synovium Using the Severe Combined Immunodeficiency Mouse Model Joerg Schedel, Thomas Pap, Ulf Muller-Ladner, Renate E. Gray, and Steffen Gay Retroviral Transduction of Antigen-Specific CD4+ T Cells for Local Delivery of Regulatory Molecules Gina L. Costa and C. Garrison Fathman Gene Transfer to Lymphocytes Targeting Cartilagineous Collagen Type II Alexander E. Annenkov and Yuti Chernajovsky Gene Therapy in Murine Arthritis:

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Reviews

"It is indeed most helpful to those practicing Rheumatology. The author is a credible authority in the subject matter of the book...This book covers an exhaustive list of therapeutic topics. From familiar- such as Non Steroidal Drugs to unusual such as Apoptosis Regulation have been discussed in detail. Subjects such as Gene Therapy are especially well covered. The unique aspect of this book has to be its ability to discuss the latest knowledge in depth without losing sight of its primary objective; examining its clinical applicability...this book will prove to be of incomparable value; especially to practicing rheumatologists. It lays forth clearly what can be offered to the patient and why it may be of benefit when faced with the bewildering choices of therapeutic options available today. There are really no other books quite like it." -Doody's Health Sciences Book Review Journal "This book could not have been published at a better time from the rheumatology trainee's point of view. It is written in a coherent and concise manner, which serves as an excellent source for all aspects of therapeutics in the rheumatic diseases. Furthermore, the frequent use of diagrams and graphs allowed emphasis of key points. This publication links the basic science of rheumatic diseases to a comprehensive text of therapeutic mechanisms and efficacy." -The Journal of Rheumatology

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