Table of Contents

Synthetic Chemistry and Biochemistry: Platinum DNA Chemistry; S. Lippard. New Insights about the Interaction of Cisplatinum with Intracellular Components; J. Reedijk. Modelling Platinum-DNA Interactions; B. Lippert. From the Modelization of DNA Platination to the Conception of New Drugs; J.C. Chottard. Biochemical and Molecular Pharmacology: Role of Membrane Ion Transport in Cisplatin Accumulation; P.A. Andrews. Enhancement of the Antiproliferative Effect of Cisdiamminedichloroplatinum (II) and Other Antitumor Agents by Inhibitors of Enzymes Involved in Growth Factor SignalTransduction; H.H. Grunicke. Signal Transduction Pathway Regulation of DDP Sensitivity; S.B. Howell. The Role of Platinum-DNA Lesions in the Inhibition of DNA Replication; N.P. Johnson. Toxicology and Clinical Pharmacology of New Drugs: Pharmacokietics of Carboplatin in Children and the Development of a Pediatric Dose Equation; H. Calvert. Clinical Studies with Cisplatin Analogues, 254S, DWA2114R and NK121; H. Majima. Clinical Trials: Dose Intensity Analysis May Help Resolve Issues in Chemotherapy with Platinum Compounds; W. Hryniuk. Cisplatin DoseIntensity in Testicular Cancer Treatment: Analysis of a Randomized Clinical Trial; C.R. Nichols, et al. 39 additional articles. Index.