1. Introduction.- 2. The coronary circulation.- 3. Introduction to invasive assessment of the coronary circulation.- 4. Fractional flow reserve From Coronary Pressure to Coronary Flow.- 5. Practical set-up of coronary pressure measurement.- 6. Pitfalls in coronary pressure measurement.- 7. Validation of fractional flow reserve in animals.- 8. Validation of fractional flow reserve in humans.- 9. Independence of fractional flow reserve of hemodynamic loading conditions.- 10. Fractional flow reserve in normal coronary arteries.- 11. Fractional flow reserve to distinguish significant stenosis: use at diagnostic catheterization Cut-off values do detect reversible ischemia.- 12. Fractional flow reserve to assess intermediate stenosis Comparison to non-invasive tests.- 13. FFR in some specific conditions.- 14. Fractional flow reserve for evaluation of coronary interventions.- 15. Fractional flow reserve and clinical outcome.- 16. Assessment of collateral blood flow by coronary pressure measurement.- 17. Clinical cases.- 18. Conclusions and perspectives for the future.

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